Presented By: Brigid Hogan, Ph.D., F.R.S. George Barth Geller Professor
and Chair Department of Cell Biology Duke
University Medical Center The Hogan lab studies the cellular and genetic
mechanisms underlying the development, maintenance
and repair of organs derived from embryonic foregut endoderm. We focus
on the lung, using the mouse as a model organism. We
are particularly interested in the stem cells that play an essential
role in the development of the lung and its repair
after injury.
We are driven by both curiosity and by practical considerations. We
believe that in the long run knowledge about the cells,
signaling pathways and genetic programs required for the growth,
development and regeneration of the lung will translate
into new approaches to clinical problems. These include promoting lung
maturation in premature babies and repair of lung
epithelium after damage by harmful agents, inhibiting pulmonary
fibrosis, and blocking the growth of tumors.