2012-2013 Bioengineering

UCLA
5121 Engineering V
Box 951600
Los Angeles, CA 90095-1600

 

(310) 267-4985
fax: (310) 794-5956
e-mail: bioeng@ea.ucla.edu
http://www.bioeng.ucla.edu

Benjamin M. Wu, D.D.S., Ph.D., Chair
Daniel T. Kamei, Ph.D., Vice Chair

Faculty

Professors

Denise Aberle, M.D.

Mark S. Cohen, Ph.D., in Residence

Linda L. Demer, M.D., Ph.D

Timothy J. Deming, Ph.D.

James Dunn, M.D., Ph.D.

Warren S. Grundfest, M.D., FACS

Chih-Ming Ho, Ph.D. (Ben Rich Lockheed Martin Professor of Aeronautics)

Bahram Jalali, Ph.D.

Wentai Liu, Ph.D.

Gerard C.L. Wong, Ph.D.

Benjamin M. Wu, D.D.S., Ph.D.

Professor Emeriti

Edward R.B. McCabe, M.D., Ph.D. (Mattel Executive Endowed Professor Emeritus of Pediatrics)

Associate Professors

Pei-Yu Chiou, Ph.D.

Dino Di Carlo, Ph.D.

Daniel T. Kamei, Ph.D.

Aydogan Ozcan, Ph.D.

Jacob J. Schmidt, Ph.D.

Assistant Professors

Daniel B. Ennis, Ph.D.

Andrea M. Kasko, Ph.D.

Adjunct Professor

Debiao Li, Ph.D.

Adjunct Assistant Professors

Martin O. Culjat, Ph.D.

Kayvan Niazi, Ph.D.

Shahrooz Rabizadeh, Ph.D.

Bill J. Tawil, M.B.A., Ph.D.

Affiliated Faculty

Professors

Marvin Bergsneider, M.D., in Residence (Neurosurgery)

Francisco Bezanilla, Ph.D. (Physiology)

Douglas L. Black, Ph.D. (Microbiology, Immunology, and Molecular Genetics)

Gregory P. Carman, Ph.D. (Mechanical and Aerospace Engineering)

Yong Chen, Ph.D. (Mechanical and Aerospace Engineering)

Samson Chow, Ph.D. (Molecular and Medical Pharmacology)

Joseph L. Demer, M.D., Ph.D. (Neurology, Ophthalmology)

Joseph J. DiStefano III, Ph.D. (Computer Science, Medicine)

Bruce S. Dunn, Ph.D. (Materials Science and Engineering)

V. Reggie Edgerton, Ph.D. (Integrative Biology and Physiology)

Alan Garfinkel, Ph.D. (Cardiology, Integrative Biology and Physiology)

Robin L. Garrell, Ph.D. (Chemistry and Biochemistry)

Robert P. Gunsalus, Ph.D. (Microbiology, Immunology, and Molecular Genetics)

Vijay Gupta, Ph.D. (Mechanical and Aerospace Engineering)

Jack W. Judy, Ph.D. (Electrical Engineering)

Chang-Jin Kim, Ph.D. (Mechanical and Aerospace Engineering)

H. Phillip Koeffler, M.D. (Medicine)

Jody E. Kreiman, Ph.D., in Residence (Surgery)

Elliot M. Landaw, M.D., Ph.D. (Biomathematics)

James C. Liao, Ph.D. (Chemical and Biomolecular Engineering)

Karen M. Lyons, Ph.D. (Molecular, Cell, and Developmental Biology, Orthopaedic Surgery)

Aman Mahajan, M.D. (Anesthesiology)

Thomas G. Mason, Ph.D. (Chemistry and Biochemistry, Physics and Astronomy)

Harry McKellop, Ph.D., in Residence (Orthopaedic Surgery)

Istvan Mody, Ph.D. (Neurology, Physiology)

Harold G. Monbouquette, Ph.D. (Chemical and Biomolecular Engineering)

Samuel S. Murray, M.D., Ph.D., in Residence (Medicine)

Peter M. Narins, Ph.D. (Ecology and Evolutionary Biology, Integrative Biology and Physiology)

Ichiro Nishimura, D.D.S., D.M.Sc., D.M.D. (Dentistry)

Zhilin Qu, Ph.D., in Residence (Cardiology, Medicine)

Dario Ringach, Ph.D. (Neurobiology, Psychology)

Michael Sofroniew, M.D., Ph.D. (Neurobiology)

Igor Spigelman, Ph.D. (Dentistry)

Ren Sun, Ph.D. (Molecular and Medical Pharmacology)

Yi Tang, Ph.D. (Chemical and Biomolecular Engineering)

Ricky Taira, Ph.D, in Residence (Radiological Sciences)

Michael Teitell, M.D., Ph.D. (Pathology and Laboratory Medicine, Pediatrics)

Albert Thomas, Ph.D., in Residence (Radiological Sciences)

Paul M. Thompson, Ph.D., in Residence (Neurology)

James G. Tidball, Ph.D. (Integrative Biology and Physiology)

Kang Ting, D.M.D., D.M.Sc. (Dentistry)

Arthur Toga, Ph.D. (Neurology)

Cun-Yu Wang, Ph.D., DDS (Oral Biology, Medicine)

Jeffrey Wang, M.D. (Orthopaedic Surgery)

David Wong, Ph.D. (Dentistry)

Lily Wu, Ph.D. (Molecular and Medical Pharmacology, Urology)

Hong Zhou, Ph.D. (Microbiology, Immunology, and Molecular Genetics)

Professor Emeritus

Tony Chan, Ph.D. (Mathematics)

Associate Professors

Alex Bui, Ph.D. (Radiological Sciences)

Katrina Dipple, M.D., Ph.D. (Human Genetics, Pediatrics)

Jeff D. Eldredge, Ph.D. (Mechanical and Aerospace Engineering)

Xiao Hu, Ph.D., in Residence (Neurosurgery, Surgery)

Yongho Ju, Ph.D. (Mechanical and Aerospace Engineering)

Daniel S. Levi, Ph.D. (Pediatrics)

Dejan Markovic, Ph.D. (Electrical Engineering)

Heather D. Maynard, Ph.D. (Chemistry and Biochemistry)

Matteo Pellegrini, Ph.D. (Molecular, Cell, and Developmental Biology)

Laurent Pilon, Ph.D. (Mechanical and Aerospace Engineering)

Desmond Smith, Ph.D. (Molecular and Medical Pharmacology)

Hsian-Rong Tseng, Ph.D. (Molecular and Medical Pharmacology)

Danny JJ Wang, Ph.D., in Residence (Neurology)

Assistant Professors

James Bisley, Ph.D. (Neurobiology)

Louis Bouchard, Ph.D. (Chemistry and Biochemistry)

Christopher Giza, Ph.D., in Residence (Neurosurgery, Surgery)

Thomas G. Graeber, Ph.D. (Molecular and Medical Pharmacology)

William S. Klug, Ph.D. (Mechanical and Aerospace Engineering)

Min Lee, Ph.D. (Dentistry)

Nader Pouratian, Ph.D. (Neurosurgery)

Amy C. Rowat, Ph.D. (Integrative Biology and Physiology)

Dan Ruan, Ph.D. (Radiation Oncology)

Tatiana Segura, Ph.D. (Chemical and Biomolecular Engineering)

Ladan Shams, Ph.D. (Psychology)

Zhouwen Tu, Ph.D., in Residence (Neurology)

R. Michael van Dam, Ph.D. (Molecular and Medical Pharmacology)

Xinshu Xiao, Ph.D. (Integrative Biology and Physiology)

Adjunct Professor

Howard Winet, Ph.D. (Orthopaedic Surgery)

Scope and Objectives

Faculty members in the Department of Bioengineering believe that the interface between biology and the physical sciences represents an exciting area for science in the twenty-first century. Bioengineering has established itself as an independent field and engineering discipline, resulting in the formation of many new bioengineering departments and the redefinition of established programs. Faculty members have embraced this unique opportunity by developing an innovative curriculum, creating state-of-the-art facilities, and performing cutting-edge research.

Instead of treating bioengineering as an application of traditional engineering, it is taught as an applied science discipline in its own right. The bioengineering program is a structured compilation of unique forward-looking courses dedicated to producing graduates who are well-grounded in the fundamental sciences and highly proficient in rigorous analytical engineering tools necessary for lifelong success in the wide range of possible bioengineering careers. With these courses and a strong emphasis on research, the program provides a unique engineering educational experience that responds to the growing needs and demands of bioengineering.

Department Mission

The mission of the Bioengineering Department is to perform cutting-edge research that benefits society and to train future leaders in the wide range of possible bioengineering careers by producing graduates who are well-grounded in the fundamental sciences, adept at addressing open-ended problems, and highly proficient in rigorous analytical engineering tools necessary for lifelong success.

Undergraduate Program Objectives

The goal of the bioengineering curriculum is to train future leaders by providing students with the fundamental scientific knowledge and engineering tools necessary for graduate study in engineering or scientific disciplines, continued education in health professional schools, or employment in industry. There are five main objectives: graduates (1) participate in graduate, professional, and continuing education activities that demonstrate an appreciation for lifelong learning, (2) demonstrate professional, ethical, societal, environmental, and economic responsibility (e.g., by active membership in professional organizations), (3) demonstrate the ability to identify, analyze, and solve complex, open-ended problems by creating and implementing appropriate designs, (4) work effectively in teams consisting of people of diverse disciplines and cultures, and (5) be effective written and oral communicators in their professions or graduate/professional schools.

Undergraduate Study

The Bioengineering major is a designated capstone major. Utilizing knowledge from previous courses and new techniques learned from the capstone courses, undergraduate students work in teams to apply advanced knowledge of mathematics, science, and engineering principles to address problems at the interface of biology and engineering and to develop innovative bioengineering solutions to meet specific sets of design criteria. Coursework entails construction of student designs, project updates, presentation of projects in written and oral format, and team competition.

Bioengineering B.S.

Capstone Major

Preparation for the Major

Required: Bioengineering 10; Chemistry and Biochemistry 20A, 20B, 20L, 30A, 30AL, 30B, 30BL; Computer Science 31; Life Sciences 2 (satisfies HSSEAS GE life sciences requirement), 3, 4, 23L; Mathematics 31A, 31B, 32A, 32B, 33A, 33B; Physics 1A, 1B, 1C, 4AL, 4BL.

The Major

Required: Bioengineering 100, C106, 110, 120, 165EW (or Engineering 183EW or 185EW), 167L, 176, 180, Chemistry and Biochemistry 153A, Electrical Engineering 100; three technical breadth courses (12 units) selected from an approved list available in the Office of Academic and Student Affairs; two capstone design courses (Bioengineering 177A, 177B); and three major field elective courses (12 units) from Bioengineering C101, CM102, CM103, C104, C105, C131, CM140, CM145, C147, CM150, CM150L, C170, C171, CM178, C179, 180L, 181, 181L, C183, C185, CM186, CM187, 199 (8 units maximum).

The three technical breadth and three major field elective courses may also be selected from one of the following tracks. Bioengineering majors cannot take bioengineering technical breadth courses to fulfill the technical breadth requirement.

Biomaterials and Regenerative Medicine: Bioengineering C104, C105, CM140, C147, C183, C185, 199 (8 units maximum), Chemistry and Biochemistry C140, C181, Materials Science and Engineering 104, 110, 111, 120, 130, 132, 140, 143A, 150, 151, 160, 161, Molecular, Cell, and Developmental Biology 168. The above materials science and engineering courses may be used to satisfy the technical breadth requirement.

Biomedical Devices: Bioengineering C131, C172, 199 (8 units maximum), Electrical Engineering 102, CM150 (or Mechanical and Aerospace Engineering CM180), CM150L (or Mechanical and Aerospace Engineering CM180L), Mechanical and Aerospace Engineering C187L. The electrical engineering or mechanical and aerospace engineering courses listed above may be used to satisfy the technical breadth requirement.

For Bioengineering 199 to fulfill a track requirement, the research project must fit within the scope of the track field, and the research report must be approved by the supervisor and vice chair.

For information on University and general education requirements, see Requirements for B.S. Degrees on page 19 or http://www.registrar.ucla.edu/ge/.

Graduate Study

For information on graduate admission, see Graduate Programs, page 23.

The following introductory information is based on the 2012-13 edition of Program Requirements for UCLA Graduate Degrees. Complete annual editions of Program Requirements are available at http://grad.ucla.edu/gasaa/library/pgmrqintro.htm. Students are subject to the detailed degree requirements as published in Program Requirements for the year in which they enter the program.

The Bioengineering Department offers Master of Science (M.S.) and Doctor of Philosophy (Ph.D.) degrees in Bioengineering.

Bioengineering M.S.

Students are expected to complete 42 units, which in most cases include either Bioengineering C201, CM202, and CM203, or C204, C205, and C206, and two courses from their area of study. The M.S. degree is offered under both the thesis plan and comprehensive examination plan. Under the thesis plan, 8 units of thesis work may be applied toward the unit requirements for the degree. The comprehensive examination plan consists entirely of coursework (12 courses) and a comprehensive examination. Eight of the 12 courses must be graduate (200-level) courses, and students must maintain a grade-point average of B or better in both upper division and graduate courses. Three Bioengineering 299 courses (6 units total) are also required.

Bioengineering Ph.D.

The Ph.D. program prepares students for advanced study and research in bioengineering. The Ph.D. preliminary examination typically consists of both written and oral parts. To receive a pass on the examination, students must receive a pass on both parts. An oral qualifying/advancement to candidacy examination, coursework for two minor fields of study, and defense of the dissertation are also required. The major field consists of six courses, and each minor field consists of three 4-unit courses, of which two must be graduate (200-level) courses. One minor must be in another field of biomedical engineering. Students must maintain a grade-point average of 3.25 or better in all courses.

Fields of Study

Biomaterials, Tissue Engineering, and Biomechanics

Three subfields—biomechanics, biomaterials, and tissue engineering—encompass this broad field. The properties of bone, muscles, and tissues, the replacement of natural materials with artificial compatible and functional materials such as polymer composites, ceramics, and metals, and the complex interactions between implants and the body are studied.

Course Requirements

Core Courses (Required). Bioengineering 176, C201, C204, C205, C206, and two courses from CM240, CM278, C283, C285, Molecular, Cell, and Developmental Biology 100, 104AL, 138, M140, 165A, 168.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Bioengineering website at http://www.bioeng.ucla.edu.

Biomedical Instrumentation

The biomedical instrumentation field trains bioengineers in the applications and development of instrumentation used in medicine and biotechnology. Examples include the use of lasers in surgery and diagnostics, sensors for detection and monitoring of disease, and microelectromechanical systems (MEMS) devices for controlled drug delivery, surgery, or genetics. The principles underlying each instrument and the specific needs in medical applications are emphasized.

Course Requirements

Core Courses (Required). Bioengineering C201, C204, C205, C206, CM250A, Electrical Engineering 100.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Bioengineering website at http://www.bioeng.ucla.edu.

Biomedical Signal and Image Processing

The biomedical signal and image processing field encompasses techniques for the acquisition, processing, classification, and analysis of digital biomedical signals, images, and related information, classification and analysis of biomedical data, and decision support of clinical processes. Sample applications include (1) digital imaging research utilizing modalities such as X-ray imaging, computed tomography (CT), and magnetic resonance (MR), positron emission tomography (PET) and SPECT, optical microscopy, and combinations such as PET/MR, (2) signal processing research on hearing to voice recognition to wireless sensors, and (3) bioinformatics research ranging from image segmentation for content-based retrieval from databases to correlating clinical findings with genomic markers. Graduates of the program integrate advanced digital processing and artificial intelligence technologies with healthcare activities and biomedical research. They are prepared for careers involving innovation in the fields of signal processing, medical imaging, and medical-related informatics in either industry or academia.

Course Requirements

Students selecting biomedical signal and image processing as a minor field must take three courses, of which at least two must be graduate (200-level) courses.

Core Courses (Required). Bioengineering C201, CM202, CM203, M214A, Electrical Engineering 113, 211A.

Electives. Bioengineering M248, Biomedical Physics 200A, 200B, M219, 222, Computer Science 143, 161, Electrical Engineering 214B.

Remedial Courses. Electrical Engineering 102, Program in Computing 10A, 10B.

Biosystem Science and Engineering

Graduate study in biosystem science and engineering is intended for science or engineering students interested in systems biology biosystems or biomedical systems, with an emphasis on systems and integration. This encompasses the systems engineering/cybernetics-based integrative properties or behavior of living systems, including their regulation, control, integration, and intercommunication mechanisms, and their associated measurement, visualization, and mathematical and computer modeling.

The program provides directed interdisciplinary biosystem studies to establish a foundation in system and information science, mathematical modeling, measurement and integrative biosystem science, as well as related specialized life sciences domain studies. It fosters careers in research and teaching in systems biology engineering, medicine, and/or the biomedical sciences, or research and development in the biomedical or pharmaceutical industry. At the system and integration level, biocybernetics methodology is quite broadly applicable to a large spectrum of biomedical problems.

Typical research areas include basic and clinical problems in biomedical systems, systems biology, all types of biocontrol systems, imaging systems, pharmaceutical systems, biotechnology systems, bioinformatics, genomics, neuroscience, and remote sensing systems for the life sciences.

Faculty research areas include computational biology, computational biochemistry, and metabolism; computational cardiology and neuroendocrinology; biomodeling of diseases, cellular processes, metabolic control systems, and gene networks; modeling in genomics, pharmacokinetics, and pharmacodynamics; vision, robotics, speech processing, neuroscience, artificial and real neural network modeling, normative expert systems, wireless remote sensing systems, telemedicine, visualization, and virtual clinical environments.

Course Requirements

Biosystem science and engineering can serve as a minor field for other Ph.D. majors if students complete the following courses with a grade-point average of B+: Bioengineering CM286, M296A, and one additional graduate-level elective from the additional foundations or electives list.

Core Courses (Required). Bioengineering C201, CM202, CM203, CM286, CM287, and either M296A or Biomathematics 220.

Electives. Bioengineering M248, CM287, M296D, Biomathematics 206, M230, Computer Science 161, 170A, 267B, Electrical Engineering 113, 131A, 132A, 141, 142, 211A, M214A, 214B, 232E, CM250A, M250B, CM250L, M252, 260A, 260B, Mathematics 151A, 151B, 155, 170A, Physics 210B, 231B, Statistics 100A, 100B.

Medical Imaging Informatics

The objective of the medical imaging informatics field is to train students in imaging-based medical informatics. Specifically, the program’s aims are to enable (1) students from engineering backgrounds to become familiar with aspects of clinical and medical environments, such that they are able to appropriately apply their skills and knowledge in these domains, (2) students from medical backgrounds to learn sufficient expertise in current information and engineering technologies to address specific problems within clinical environments, (3) all students to be experts within the field of imaging-based medical informatics, becoming experienced in dealing with diverse biomedical data (imaging and text), and (4) all students to learn to work in a multidisciplinary group of researchers and individuals, enabling new developments within the field.

The underlying goal is to foster a community for students and faculty members from multiple disciplines (represented by individuals from the Schools of Engineering, Education and Information Studies, Medicine, and Public Health) to participate in the growing area of medical imaging informatics.

Course Requirements

Core Courses (Required). Bioengineering 220, 221, 223A, 223B, 223C, 224A, 224B, M226, M227, M228, Human Genetics 210.

Electives. Biomedical Physics 210, 214, Biostatistics 213, M234, 276, Computer Science 217A, 240A, 240B, 241A, 241B, 244A, 245A, 246, 262A, 262B, M262C, 263A, 263B, 265A, 268, M276A, 276B, Electrical Engineering M202B, 211A, M217, Information Studies 228, 246, 272, 277, Linguistics 218, 232, Neuroscience CM272.

Molecular and Cellular Bioengineering

The field of molecular and cellular bioengineering encompasses the engineering of enzymes, cellular metabolism, biological signal transduction, and cell-cell interactions. Research emphasizes the fundamental basis for diagnosis, disease treatment, and redesign of cellular functions at the molecular level. The field interacts closely with the fields of bioinstrumentation (MEMS), tissue engineering, and neuroengineering. Graduates of the program are targeted principally for employment in academia, in government research laboratories, and in the biotechnology, pharmaceutical, and biomedical industries.

Course Requirements

Core Courses (Required). Bioengineering C201, C204, C205, C206, and two courses from 100, M184, M215, M225, CM245, C283, CM286, CM287, Biomathematics 220, M270, M271, Computer Science 170A, Mathematics 146, 151A, Physiological Science 134, Statistics 200B.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Bioengineering website at http://www.bioeng.ucla.edu.

Neuroengineering

The neuroengineering field is a joint endeavor between the Neuroscience Interdepartmental Ph.D. Program in the Geffen School of Medicine and the Bioengineering Department in HSSEAS.

The objectives of the neuroengineering field are to enable (1) students with a background in engineering to develop and execute projects that address problems that have a neuroscientific base, (2) students with a background in biological sciences to develop and execute projects that make use of state-of-the-art technology, and (3) all trainees to develop the capacity for the multidisciplinary teamwork that is necessary for new scientific insights and dramatic technological progress. Courses and research projects are cosponsored by faculty members in both HSSEAS and the Brain Research Institute (BRI).

Requisites for Admission. Students entering the neuroengineering program have graduated with undergraduate degrees in engineering, physics, chemistry, or one of the life sciences (for example, biology, microbiology, immunology, and molecular genetics, molecular, cell, and developmental biology, neuroscience, physiology, or psychology). Engineering students must have taken at least one undergraduate course in biology, one course in chemistry, and a year of physics. Students from nonengineering backgrounds are required to have taken courses in undergraduate calculus, differential equations, and linear algebra, in addition to at least a year of undergraduate courses in each of the following: organic chemistry and biochemistry, physics, and biology. Students lacking one or more requisite courses, if they are otherwise admissible, are provided an opportunity for appropriate coursework or tutorial during the summer before they enter the neuroengineering program.

Written Preliminary Examination. The Ph.D. preliminary examination typically consists of three written parts—two in neuroscience and one in neuroengineering. To receive a pass on the examination, students must receive a pass on all parts. Students who fail the examination may repeat it only once, subject to approval of the faculty examination committee.

Students who are in a field other than neuroengineering and who select neuroengineering as a minor must take Bioengineering M260, M263, and Neuroscience 205.

Core Courses (Required). Bioengineering M260, Neuroscience M202, 207, and either Bioengineering M263 or Neuroscience 205.

Electives. During the first and second years, students take at least three courses selected from a menu of new and existing courses.

Bioengineering category: Bioengineering C201, M261A, M261B, M261C.

Microelectromechanical systems (MEMS) category: Bioengineering CM250A, Mechanical and Aerospace Engineering CM280L, 284.

Neuroscience category: Neuroscience M201, M273.

Signal processing category: Electrical Engineering 210A, M214A, M217. Remedial courses taken as necessary.

Students without previous exposure to MEMS should take Bioengineering CM150L; those without previous exposure to neuroscience should take Physiological Science 111A; those without previous exposure to signal processing should take Electrical Engineering 102 and 113. Both courses are offered every term.

Seminars (First-Year). Two seminars in problem-based approaches to neuroengineering are required. All first-year students take a new graduate seminar series in Winter and Spring Quarters which is co-taught each term by one instructor from HSSEAS and one from the Brain Research Institute. Each seminar introduces students to a single area of neuroengineering and challenges them to develop critical skills in evaluating primary research papers and to design new approaches to current problems. Topics include pattern generation, sensory signal processing, initiation and control of movement, microsensors, neural networks, photonics, and robotics.

Research Seminars. In addition to the formal coursework listed above, all students attend a series of weekly research seminars that allow both students and faculty members to become more conversant with the broad range of subjects in neuro-engineering.

Seminars (Second-Year). All second-year students take a seminar course each term specifically designed for the neuroengineering program. Each course is co-taught by one faculty member from the Brain Research Institute and one from HSSEAS and often include outside UCLA faculty speakers or members of the Industrial Advisory Board.

Faculty Areas of Thesis Guidance

Professors

Denise Aberle, M.D. (Kansas, 1979)

Medical imaging informatics: imaging-based clinical trials, medical data visualization

Mark S. Cohen, Ph.D. (Rockefeller, 1985)

Rapid methods of MR imaging, fusion of electrophyisology and fMRI, advanced approaches to MR data analysis, ultra-low field MRI using SQUID detection, low energy focused ultrasound for neurostimulation

Linda L. Demer, M.D., Ph.D. (Johns Hopkins, 1983)

Vascular biology, biomineralization, vascular calcification, mesenchymal stem cells

Timothy J. Deming, Ph.D. (UC Berkeley, 1993)

Polymer synthesis, polymer processing, supramolecular materials, organometallic catalysis, biomimetic materials, polypeptides

James Dunn, M.D., Ph.D. (Harvard, MIT, 1992)

Tissue engineering, stem cell therapy, regenerative medicine

Warren S. Grundfest, M.D., FACS (Columbia, 1980)

Excimer laser, minimally invasive surgery, biological spectroscopy

Chih-Ming Ho, Ph.D. (Johns Hopkins, 1974)

Molecular mechanics, nanofluidics, and bio-nano research

Bahram Jalali, Ph.D. (Columbia, 1989)

RF photonics, fiber-optic integrated circuits, integrated optics, microwave photonics

Wentai Liu, Ph.D. (Michigan, Ann Arbor, 1983)

Neural engineering

Gerald C.L. Wong, Ph.D. (UC Berkeley, 1994)

Antimicrobials and antibiotic-resistant pathogens, bacterial communities, cystic fibrosis, apoptosis proteins and cancer therapeutics, disinfection and water purification, self-assembly in biology and biotechnology, physical chemistry of solvation, soft condensed matter physics, biophysics

Benjamin M. Wu, D.D.S. (U. Pacific, 1987), Ph.D. (MIT, 1997)

Biomaterials, cell-material interactions, materials processing, tissue engineering, prosthetic and regenerative dentistry

Professor Emeriti

Edward R.B. McCabe, Ph.D. (USC, 1972), M.D. (USC, 1974)

Stem cell identification, regenerative medicine, systems biology

Associate Professors

Pei-Yu Chiou, Ph.D. (UC Berkeley, 2005)

Optofluidics systems

Dino Di Carlo, Ph.D. (UC Berkeley, 2006)

Microfluidics, biomedical microdevices, cellular diagnostics, cell analysis and engineering

Daniel T. Kamei, Ph.D. (MIT, 2001)

Molecular cell bioengineering, rational design of molecular therapeutics, systems-level analyses of cellular processes, drug delivery, diagnostics

Aydogan Ozcan, Ph.D. (Stanford, 2005)

Photonics, nano- and bio-technology

Jacob J. Schmidt, Ph.D. (Minnesota, 1999)

Bioengineering and biophysics at micro and nanoscales, membrane protein engineering, biological-inorganic hybrid devices

Assistant Professors

Daniel B. Ennis, Ph.D. (Johns Hopkins, 2004)

MRI, cardiovascular pathophysiology, image processing, continuum mechanics, tensor analysis, soft tissue biomechanics

Andrea M. Kasko, Ph.D. (U. Akron, 2004)

Polymer synthesis, biomaterials, tissue engineering, cell-material interactions

Adjunct Professor

Debiao Li, Ph.D. (U. Virginia, 1992)

Development and clinical application of fast MR imaging techniques for the evaluation of the cardiovascular system

Adjunct Assistant Professors

Martin O. Culjat, Ph.D. (UCLA, 2005)

Devices for image-guided surgical and interventional techniques

Kayvan Niazi, Ph.D. (UCLA, 2000)

Molecular and cellular bioengineering, immunotherapeutics

Shahrooz Rabizadeh, Ph.D. (UCLA, 1999)

Molecular and cellular bioengineering, drug discovery in cancer and neurodegeneration

Bill J. Tawil, M.B.A. (California Lutheran, 2006), Ph.D. (McGill, 1992)

Skin tissue engineering, bone tissue engineering, vascular tissue engineering, wound healing

Affiliated Faculty

For areas of thesis guidance, see http://www.bioeng.ucla.edu/people/faculty/affiliate-faculty-1.

Lower Division Courses

10. Introduction to Bioengineering. (2) Lecture, two hours; discussion, one hour; outside study, three hours. Preparation: high school biology, chemistry, mathematics, physics. Introduction to scientific and technological bases for established and emerging subfields of bioengineering, including biosensors, bioinstrumentation, and biosignal processing, biomechanics, biomaterials, tissue engineering, biotechnology, biological imaging, biomedical optics and lasers, neuroengineering, and biomolecular machines. Letter grading. Mr. Deming (F)

19. Fiat Lux Freshman Seminars. (1) Seminar, one hour. Discussion of and critical thinking about topics of current intellectual importance, taught by faculty members in their areas of expertise and illuminating many paths of discovery at UCLA. P/NP grading.

99. Student Research Program. (1 to 2) Tutorial (supervised research or other scholarly work), three hours per week per unit. Entry-level research for lower division students under guidance of faculty mentor. Students must be in good academic standing and enrolled in minimum of 12 units (excluding this course). Individual contract required; consult Undergraduate Research Center. May be repeated. P/NP grading.

Upper Division Courses

100. Bioengineering Fundamentals. (4) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Mathematics 32A, Physics 1B. Fundamental basis for analysis and design of biological and biomedical devices and systems. Classical and statistical thermodynamic analysis of biological systems. Material, energy, charge, and force balances. Introduction to network analysis. Letter grading. Mr. Kamei (W)

C101. Engineering Principles for Drug Delivery. (4) (Formerly numbered Biomedical Engineering C101.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Mathematics 33B, Physics 1B. Application of engineering principles for designing and understanding delivery of therapeutics. Discussion of physics and mathematics required for understanding colloidal stability. Analysis of concepts related to both modeling and experimentation of endocytosis and intracellular trafficking mechanisms. Analysis of diffusion of drugs, coupled with computational and engineering mathematics approaches. Concurrently scheduled with course C201. Letter grading. Mr. Kamei (F)

CM102. Basic Human Biology for Bioengineers I. (4) (Formerly numbered Biomedical Engineering CM102.) (Same as Physiological Science CM102.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM202. Letter grading. Mr. Grundfest (F)

CM103. Basic Human Biology for Bioengineers II. (4) (Formerly numbered Biomedical Engineering CM103.) (Same as Physiological Science CM103.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM203. Letter grading. Mr. Grundfest (W)

C104. Physical Chemistry of Biomacromolecules. (4) (Formerly numbered M104.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3, 23L. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Concurrently scheduled with course C204. Letter grading. Ms. Kasko (F)

C105. Biopolymer Chemistry and Bioconjugates. (4) (Formerly numbered M105.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Concurrently scheduled with course C205. Letter grading. Mr. Deming (W)

C106. Topics in Biophysics, Channels, and Membranes. (4) (Formerly numbered M106.) Lecture, three hours; discussion, one hour; outside study, eight hours. Enforced requisites: Chemistry 20B, Life Sciences 2, 3, 4, 23L, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Concurrently scheduled with course C206. Letter grading. Mr. Schmidt (F)

C107. Polymer Chemistry for Bioengineers. (4) (Formerly numbered M107.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: course C104 or C105. Fundamental concepts of polymer synthesis, including step-growth, chain growth (ionic, radical, metal catalyzed), and ring-opening, with focus on factors that can be used to control chain length, chain length distribution, and chain-end functionality, chain copolymerization, and stereochemistry in polymerizations. Presentation of applications of use of different polymerization techniques. Concepts of step-growth, chain-growth, ring-opening, and coordination polymerization, and effects of synthesis route on polymer properties. Lectures include both theory and practical issues demonstrated through examples. Concurrently scheduled with course C207. Letter grading. Mr. Deming (W)

110. Biotransport and Bioreaction Processes. (4) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: course 100, Mathematics 33B. Introduction to analysis of fluid flow, heat transfer, mass transfer, binding events, and biochemical reactions in systems of interest to bioengineers, including cells, tissues, organs, human body, extracorporeal devices, tissue engineering systems, and bioartificial organs. Introduction to pharmacokinetic analysis. Letter grading. Mr. Kamei (Sp)

120. Biomedical Transducers. (4) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 30A, Electrical Engineering 1 or Physics 1C, Electrical Engineering 100, Mathematics 32B. Principles of transduction, design characteristics for different measurements, reliability and performance characteristics, and data processing and recording. Emphasis on silicon-based microfabricated and nanofabricated sensors. Novel materials, biocompatibility, biostability. Safety of electronic interfaces. Actuator design and interfacing control. Letter grading. Mr. Grundfest, Mr. Schmidt (W)

C131. Nanopore Sensing. (4) (Formerly numbered M131.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: courses 100, 120, Life Sciences 2, 3, 23L, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Concurrently scheduled with course C231. Letter grading. Mr. Schmidt (Sp)

CM140. Introduction to Biomechanics. (4) (Formerly numbered Biomedical Engineering CM140.) (Same as Mechanical and Aerospace Engineering CM140.) Lecture, four hours; discussion, two hours; outside study, six hours. Enforced requisites: Mechanical and Aerospace Engineering 101, 102, 156A. Introduction to mechanical functions of human body; skeletal adaptations to optimize load transfer, mobility, and function. Dynamics and kinematics. Fluid mechanics applications. Heat and mass transfer. Power generation. Laboratory simulations and tests. Concurrently scheduled with course CM240. Letter grading. Mr. Gupta (W)

CM145. Molecular Biotechnology for Engineers. (4) (Formerly numbered Biomedical Engineering CM145.) (Same as Chemical Engineering CM145.) Lecture, four hours; discussion, one hour; outside study, eight hours. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM245. Letter grading. Mr. Liao (F)

C147. Applied Tissue Engineering: Clinical and Industrial Perspective. (4) (Formerly numbered Biomedical Engineering C147.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: course CM102, Chemistry 20A, 20B, 20L, Life Sciences 1 or 2. Overview of central topics of tissue engineering, with focus on how to build artificial tissues into regulated clinically viable products. Topics include biomaterials selection, cell source, delivery methods, FDA approval processes, and physical/chemical and biological testing. Case studies include skin and artificial skin, bone and cartilage, blood vessels, neurotissue engineering, and liver, kidney, and other organs. Clinical and industrial perspectives of tissue engineering products. Manufacturing constraints, clinical limitations, and regulatory challenges in design and development of tissue-engineering devices. Concurrently scheduled with course C247. Letter grading. Mr. Wu (F)

CM150. Introduction to Micromachining and Microelectromechanical Systems (MEMS). (4) (Formerly numbered Biomedical Engineering CM150.) (Same as Electrical Engineering CM150 and Mechanical and Aerospace Engineering CM180.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Introduction to micromachining technologies and microelectromechanical systems (MEMS). Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students design microfabrication processes capable of achieving desired MEMS device. Concurrently scheduled with course CM250A. Letter grading. Mr. Judy (F)

CM150L. Introduction to Micromachining and Microelectromechanical Systems (MEMS) Laboratory. (2) (Formerly numbered Biomedical Engineering CM150L.) (Same as Electrical Engineering CM150L and Mechanical and Aerospace Engineering CM180L.) Lecture, one hour; laboratory, four hours; outside study, one hour. Requisites: course CM150, Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Hands-on introduction to micromachining technologies and microelectromechanical systems (MEMS) laboratory. Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students go through process of fabricating MEMS device. Concurrently scheduled with course CM250L. Letter grading. Mr. Judy (F)

165EW. Bioengineering Ethics. (4) (Formerly numbered 165.) Lecture, four hours; discussion, three hours; outside study, five hours. All professions have ethical rules that derive from moral theory. Bioethics is well-established discipline that addresses ethical problems about life, such as when do fertilized eggs become people? Should ending of life ever be assisted? At what cost should it be maintained? Unlike physicians, bioengineers do not make these decisions in practice. Engineering ethics addresses ethical problems about producing devices from molecules to bridges, such as when do concerns about risk outweigh concerns about cost? When are weapons too dangerous to design? At what point does benefit of committing to building devices outweigh need to wait for more scientific confirmation of their effectiveness? Bioengineers must be aware of consequences of applying such devices to all living systems. Emphasis on research and writing within engineering environments. Satisfies engineering writing requirement. Letter grading. Mr. Wu (W)

167L. Bioengineering Laboratory. (4) (Formerly numbered 182A.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisite: Chemistry 20L. Laboratory experiments in fluorescence microscopy, bioconjugation, soft lithography, and cell culture culminate in design of engineered surface for cell growth. Introduction to techniques used in laboratories and their underlying physical or chemical properties. Case studies connect laboratory techniques to current biomedical engineering research and reinforce experimental design skills. Letter grading. Mr. Di Carlo, Mr. Wong (Sp)

C170. Energy-Tissue Interactions. (4) (Formerly numbered Biomedical Engineering C170.) Lecture, three hours; outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life Sciences 3, Physics 17. Corequisite: course C170L. Introduction to therapeutic and diagnostic use of energy delivery devices in medical and dental applications, with emphasis on understanding fundamental mechanisms underlying various types of energy-tissue interactions. Concurrently scheduled with course C270. Letter grading. Mr. Grundfest (F)

C170L. Introduction to Techniques in Studying Laser-Tissue Interaction. (2) (Formerly numbered Biomedical Engineering C170L.) Laboratory, four hours; outside study, two hours. Corequisite: course C170. Introduction to simulation and experimental techniques used in studying laser-tissue interactions. Topics include computer simulations of light propagation in tissue, measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Concurrently scheduled with course C270L. Letter grading.

C171. Laser-Tissue Interaction II: Biologic Spectroscopy. (4) (Formerly numbered Biomedical Engineering C171.) Lecture, four hours; outside study, eight hours. Requisite: course C170. Designed for physical sciences, life sciences, and engineering majors. Introduction to optical spectroscopy principles, design of spectroscopic measurement devices, optical properties of tissues, and fluorescence spectroscopy biologic media. Concurrently scheduled with course C271. Letter grading. Mr. Grundfest (W)

C172. Design of Minimally Invasive Surgical Tools. (4) (Formerly numbered M172.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, 23L, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Concurrently scheduled with course C272. Letter grading. Mr. Grundfest (F)

176. Principles of Biocompatibility. (4) Lecture, four hours; discussion, two hours; outside study, six hours. Enforced requisites: course 100, Electrical Engineering 1 or Physics 1C, Mathematics 33B. Biocompatibility at systemic, tissue, cellular, and molecular levels. Biomechanical compatibility, stress/strain constitutive equations, cellular and molecular response to mechanical signals, biochemical and cellular compatibility, immune response. Letter grading. Mr. Wu (Sp)

177A. Bioengineering Capstone Design I. (4) (Formerly numbered 182B.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisites: courses 167L, 176. Lectures, seminars, and discussions on aspects of biomedical device and therapeutic design, including topics such as need finding, intellectual property, entrepreneurship, regulation, and project management. Working in teams, students develop innovative solutions to address current problems in medicine and biology. Sourcing and ordering of materials and supplies relevant to student projects. Exploration of different experimental and computational methods. Scientific presentation of progress. Letter grading. Mr. Di Carlo, Mr. Wong (F)

177B. Bioengineering Capstone Design II. (4) (Formerly numbered 182C.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisite: course 177A. Lectures, seminars, and discussions on aspects of biomedical device and therapeutic design, including meetings with scientific/clinical advisers and guest lectures from scientists in industry. Working in teams, students develop innovative solutions to address current problems in medicine and biology. Students conduct directed experiments and computational modeling, give oral presentations, write reports, and participate in bioengineering design competition. Letter grading. Mr. Di Carlo, Mr. Wong (W)

CM178. Introduction to Biomaterials. (4) (Formerly numbered Biomedical Engineering CM180.) (Same as Materials Science CM180.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 104. Engineering materials used in medicine and dentistry for repair and/or restoration of damaged natural tissues. Topics include relationships between material properties, suitability to task, surface chemistry, processing and treatment methods, and biocompatibility. Concurrently scheduled with course CM278. Letter grading. Mr. Wu (W)

C179. Biomaterials-Tissue Interactions. (4) (Formerly numbered Biomedical Engineering C181.) Lecture, three hours; outside study, nine hours. Requisite: course CM178. In-depth exploration of host cellular response to biomaterials: vascular response, interface, and clotting, biocompatibility, animal models, inflammation, infection, extracellular matrix, cell adhesion, and role of mechanical forces. Concurrently scheduled with course C279. Letter grading. Mr. Wu (Sp)

180. System Integration in Biology, Engineering, and Medicine I. (4) Lecture, three hours; discussion, two hours; outside study, seven hours. Enforced requisites: courses 100, 110, 120, Life Sciences 3, Physics 4BL. Corequisite: course 180L. Part I of two-part series. Molecular basis of normal physiology and pathophysiology, and engineering design principles of cardiovascular and pulmonary systems. Fundamental engineering principles of selected medical therapeutic devices. Letter grading. Mr. Dunn, Mr. Wu (W)

180L. System Integration in Biology, Engineering, and Medicine I Laboratory. (3) Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 180. Hands-on experimentation and clinical applications of selected medical therapeutic devices associated with cardiovascular and pulmonary disorders. Letter grading. Mr. Dunn, Mr. Wu (Sp)

181. System Integration in Biology, Engineering, and Medicine II. (4) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisite: course 180L. Corequisite: course 181L. Part II of two-part series. Molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Fundamental engineering principles of selected medical therapeutic devices. Letter grading. Mr. Dunn, Mr. Wu (W)

181L. System Integration in Biology, Engineering, and Medicine II Laboratory. (3) Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 181. Hands-on experimentation and clinical applications of molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Letter grading. Mr. Dunn, Mr. Wu (W)

C183. Targeted Drug Delivery and Controlled Drug Release. (4) (Formerly numbered M183.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Concurrently scheduled with course C283. Letter grading. Ms. Kasko (F)

M184. Introduction to Computational and Systems Biology. (2) (Formerly numbered Biomedical Engineering M184.) (Same as Computational and Systems Biology M184 and Computer Science M184.) Lecture, two hours; outside study, four hours. Requisites: Computer Science 31 (or Program in Computing 10A), Mathematics 31A, 31B. Survey course designed to introduce students to computational and systems modeling and computation in biology and medicine, providing motivation, flavor, culture, and cutting-edge contributions in computational biosciences and aiming for more informed basis for focused studies by students with computational and systems biology interests. Presentations by individual UCLA researchers discussing their active computational and systems biology research. P/NP grading. Mr. DiStefano (W)

C185. Introduction to Tissue Engineering. (4) (Formerly numbered Biomedical Engineering C185.) Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C285. Letter grading. Mr. Wu (Sp)

CM186. Computational Systems Biology: Modeling and Simulation of Biological Systems. (5) (Formerly numbered Biomedical Engineering CM186.) (Same as Computational and Systems Biology M186 and Computer Science CM186.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Corequisite: Electrical Engineering 102. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM286. Letter grading. Mr. DiStefano (F)

CM187. Thesis Research and Research Communication in Computational and Systems Biology. (2 to 4) (Formerly numbered Biomedical Engineering CM187.) (Same as Computational and Systems Biology M187 and Computer Science CM187.) Lecture, one hour; discussion, two hours; laboratory, one hour; outside study, eight hours. Requisite: course CM186. Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM287. Letter grading. Mr. DiStefano (Sp)

188. Special Courses in Bioengineering. (4) Lecture, four hours; discussion, one hour; outside study, seven hours. Special topics in bioengineering for undergraduate students taught on experimental or temporary basis, such as those taught by resident and visiting faculty members. May be repeated once for credit with topic or instructor change. Letter grading.

194. Research Group Seminars: Bioengineering. (4) Seminar, three hours. Limited to bioengineering undergraduate students who are part of research group. Study and analysis of current topics in bioengineering. Discussion of current research literature in research specialty of faculty member teaching course. Student presentation of projects in research specialty. May be repeated for credit. Letter grading.

199. Directed Research in Bioengineering. (2 to 8) Tutorial, to be arranged. Limited to juniors/seniors. Supervised individual research or investigation under guidance of faculty mentor. Culminating paper or project required. May be repeated for credit with school approval. Individual contract required; enrollment petitions available in Office of Academic and Student Affairs. Letter grading.

Graduate Courses

C201. Engineering Principles for Drug Delivery. (4) (Formerly numbered Biomedical Engineering C201.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Mathematics 33B, Physics 1B. Application of engineering principles for designing and understanding delivery of therapeutics. Discussion of physics and mathematics required for understanding colloidal stability. Analysis of concepts related to both modeling and experimentation of endocytosis and intracellular trafficking mechanisms. Analysis of diffusion of drugs, coupled with computational and engineering mathematics approaches. Concurrently scheduled with course C101. Letter grading. Mr. Kamei (F)

CM202. Basic Human Biology for Bioengineers I. (4) (Formerly numbered Biomedical Engineering CM202.) (Same as Physiological Science CM204.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM102. Letter grading. Mr. Grundfest (F)

CM203. Basic Human Biology for Bioengineers II. (4) (Formerly numbered Biomedical Engineering CM203.) (Same as Physiological Science CM203.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM103. Letter grading. Mr. Grundfest (W)

C204. Physical Chemistry of Biomacromolecules. (4) (Formerly numbered Biomedical Engineering C204.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3, 23L. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Concurrently scheduled with course C104. Letter grading. Ms. Kasko (F)

C205. Biopolymer Chemistry and Bioconjugates. (4) (Formerly numbered Biomedical Engineering C205.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Concurrently scheduled with course C105. Letter grading. Mr. Deming (W)

C206. Topics in Biophysics, Channels, and Membranes. (4) (Formerly numbered Biomedical Engineering C206.) Lecture, three hours; discussion, one hour; outside study, eight hours. Enforced requisites: Chemistry 20B, Life Sciences 2, 3, 4, 23L, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Concurrently scheduled with course C106. Letter grading. Mr. Schmidt (W)

C207. Polymer Chemistry for Bioengineers. (4) (Formerly numbered Biomedical Engineering C207.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: course C204 or C205. Fundamental concepts of polymer synthesis, including step-growth, chain growth (ionic, radical, metal catalyzed), and ring-opening, with focus on factors that can be used to control chain length, chain length distribution, and chain-end functionality, chain copolymerization, and stereochemistry in polymerizations. Presentation of applications of use of different polymerization techniques. Concepts of step-growth, chain-growth, ring-opening, and coordination polymerization, and effects of synthesis route on polymer properties. Lectures include both theory and practical issues demonstrated through examples. Concurrently scheduled with course C107. Letter grading. Mr. Deming (W)

M214A. Digital Speech Processing. (4) (Formerly numbered Biomedical Engineering M214A.) (Same as Electrical Engineering M214A.) Lecture, three hours; laboratory, two hours; outside study, seven hours. Requisite: Electrical Engineering 113. Theory and applications of digital processing of speech signals. Mathematical models of human speech production and perception mechanisms, speech analysis/synthesis. Techniques include linear prediction, filter-bank models, and homomorphic filtering. Applications to speech synthesis, automatic recognition, and hearing aids. Letter grading. Ms. Alwan (W)

M215. Biochemical Reaction Engineering. (4) (Formerly numbered Biomedical Engineering M215.) (Same as Chemical Engineering CM215.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: Chemical Engineering 101C. Use of previously learned concepts of biophysical chemistry, thermodynamics, transport phenomena, and reaction kinetics to develop tools needed for technical design and economic analysis of biological reactors. Letter grading. Mr. Liao (Sp)

M217. Biomedical Imaging. (4) (Formerly numbered Biomedical Engineering M217.) (Same as Electrical Engineering M217.) Lecture, three hours; outside study, nine hours. Requisite: Electrical Engineering 114 or 211A. Optical imaging modalities in biomedicine. Other nonoptical imaging modalities discussed briefly for comparison purposes. Letter grading.

M219. Principles and Applications of Magnetic Resonance Imaging. (4) (Formerly numbered Biomedical Engineering M219.) (Same as Biomedical Physics M219.) Lecture, three hours; discussion, one hour. Basic principles of magnetic resonance (MR), physics, and image formation. Emphasis on hardware, Bloch equations, analytic expressions, image contrast mechanisms, spin and gradient echoes, Fourier transform imaging methods, structure of pulse sequences, and various scanning parameters. Introduction to advanced techniques in rapid imaging, quantitative imaging, and spectroscopy. Letter grading.

220. Introduction to Medical Informatics. (2) (Formerly numbered Biomedical Engineering 220.) Lecture, two hours; outside study, four hours. Designed for graduate students. Introduction to research topics and issues in medical informatics for students new to field. Definition of this emerging field of study, current research efforts, and future directions in research. Key issues in medical informatics to expose students to different application domains, such as information system architectures, data and process modeling, information extraction and representations, information retrieval and visualization, health services research, telemedicine. Emphasis on current research endeavors and applications. S/U grading. Mr. Kangarloo (F)

221. Human Anatomy and Physiology for Medical and Imaging Informatics. (4) (Formerly numbered Biomedical Engineering 221.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Introduction to basic human anatomy and physiology, with particular emphasis on understanding and visualization of anatomy and physiology through medical images. Topics relevant to acquisition, representation, and dissemination of anatomical knowledge in computerized clinical applications. Topics include chest, cardiac, neurology, gastrointestinal/genitourinary, endocrine, and musculoskeletal systems. Introduction to basic imaging physics (magnetic resonance, computed tomography, ultrasound, computed radiography) to provide context for imaging modalities predominantly used to view human anatomy. Geared toward nonphysicians who require more formal understanding of human anatomy/physiology. Letter grading. Mr. El-Saden (F)

223A-223B-223C. Programming Laboratories for Medical and Imaging Informatics I, II, III. (4-4-4) (Formerly numbered Biomedical Engineering 223A-223B-223C.) Lecture, two hours; laboratory, two hours; outside study, eight hours. Designed for graduate students. Programming laboratories to support coursework in other medical and imaging informatics core curriculum courses. Exposure to programming concepts for medical applications, with focus on basic abstraction techniques used in image processing and medical information system infrastructures. Letter grading. 223A. Requisites: Computer Science 31, 32, Program in Computing 20A, 20B. Course 223A is requisite to 223B, which is requisite to 223C. Integrated with topics presented in course M227 to reinforce concepts presented with practical experience. Projects focus on understanding medical networking issues and implementation of basic protocols for healthcare environment, with emphasis on use of DICOM. Introduction to basic tools and methods used within informatics. 223B. Requisite: course 223A. Integrated with topics presented in courses 223A, M227, and M228 to reinforce concepts presented with practical experience. Projects focus on medical image manipulation and decision support systems. 223C. Requisite: course 223B. Exposure to programming concepts for medical applications, with focus on basic abstraction techniques used to extract meaningful features from medical text and imaging data and visualize results. Integrated with topics presented in courses 224B and M226 to reinforce concepts presented with practical experience. Projects focus on medical information retrieval, knowledge representation, and visualization. Mr. Meng (F,W,Sp)

224A. Physics and Informatics of Medical Imaging. (4) (Formerly numbered Biomedical Engineering 224A.) Lecture, four hours; laboratory, eight hours. Requisites: Mathematics 33A, 33B. Designed for graduate students. Introduction to principles of medical imaging and imaging informatics for nonphysicists. Overview of core imaging modalities: X ray, computed tomography (CT), and magnetic resonance (MR). Topics include signal generation, localization, and quantization. Image representation and analysis techniques such as Markov random fields, spatial characterization (atlases), denoising, energy representations, and clinical imaging workstation design. Provides basic understanding of issues related to basic medical image acquisition and analysis. Current research efforts with focus on clinical applications and new types of information made available through these modalities. Letter grading. Mr. Morioka (W)

224B. Advances in Imaging Informatics. (4) (Formerly numbered Biomedical Engineering 224B.) Lecture, four hours; outside study, eight hours. Requisite: course 224A. Overview of information retrieval techniques in medical imaging and informatics-based applications of imaging, with focus on various advances in field. Introduction to core concepts in information retrieval (IR), reviewing seminal papers on evaluating IR systems and their use in medicine (e.g., teaching files, case-based retrieval, etc.). Medical content-based image retrieval (CBIR) as motivating application, with examination of core works in this area. Techniques to realize medical CBIR, including image feature extraction and processing, feature representation, classification schemes (via machine learning), image indexing, image querying methods, and visualization of images (e.g., perception, presentation). Discussion of more advanced methods now being pursued by researchers. Letter grading. Mr. Morioka (Sp)

M225. Bioseparations and Bioprocess Engineering. (4) (Formerly numbered Biomedical Engineering M225.) (Same as Chemical Engineering CM225.) Lecture, four hours; discussion, one hour; outside study, seven hours. Corequisite: Chemical Engineering 101C. Separation strategies, unit operations, and economic factors used to design processes for isolating and purifying materials like whole cells, enzymes, food additives, or pharmaceuticals that are products of biological reactors. Letter grading. Mr. Monbouquette (W)

M226. Medical Knowledge Representation. (4) (Formerly numbered Biomedical Engineering M226.) (Same as Information Studies M253.) Seminar, four hours; outside study, eight hours. Designed for graduate students. Issues related to medical knowledge representation and its application in healthcare processes. Topics include data structures used for representing knowledge (conceptual graphs, frame-based models), different data models for representing spatio-temporal information, rule-based implementations, current statistical methods for discovery of knowledge (data mining, statistical classifiers, and hierarchical classification), and basic information retrieval. Review of work in constructing ontologies, with focus on problems in implementation and definition. Common medical ontologies, coding schemes, and standardized indices/terminologies (SNOMED, UMLS). Letter grading. Mr. Taira (Sp)

M227. Medical Information Infrastructures and Internet Technologies. (4) (Formerly numbered Biomedical Engineering M227.) (Same as Information Studies M254.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Introduction to networking, communications, and information infrastructures in medical environment. Exposure to basic concepts related to networking at several levels: low-level (TCP/IP, services), medium-level (network topologies), and high-level (distributed computing, Web-based services) implementations. Commonly used medical communication protocols (HL7, DICOM) and current medical information systems (HIS, RIS, PACS). Advances in networking, such as wireless health systems, peer-to-peer topologies, grid/cloud computing. Introduction to security and encryption in networked environments. Letter grading. Mr. Bui (F)

M228. Medical Decision Making. (4) (Formerly numbered Biomedical Engineering M228.) (Same as Information Studies M255.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Overview of issues related to medical decision making. Introduction to concept of evidence-based medicine and decision processes related to process of care and outcomes. Basic probability and statistics to understand research results and evaluations, and algorithmic methods for decision-making processes (Bayes theorem, decision trees). Study design, hypothesis testing, and estimation. Focus on technical advances in medical decision support systems and expert systems, with review of classic and current research. Introduction to common statistical and decision-making software packages to familiarize students with current tools. Letter grading. Mr. Kangarloo (W)

C231. Nanopore Sensing. (4) (Formerly numbered Biomedical Engineering C231.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: courses 100, 120, Life Sciences 2, 3, 23L, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Concurrently scheduled with course C131. Letter grading. Mr. Schmidt (F)

CM240. Introduction to Biomechanics. (4) (Formerly numbered Biomedical Engineering CM240.) (Same as Mechanical and Aerospace Engineering CM240.) Lecture, four hours; discussion, two hours; outside study, six hours. Requisites: Mechanical and Aerospace Engineering 101, 102, 156A. Introduction to mechanical functions of human body; skeletal adaptations to optimize load transfer, mobility, and function. Dynamics and kinematics. Fluid mechanics applications. Heat and mass transfer. Power generation. Laboratory simulations and tests. Concurrently scheduled with course CM140. Letter grading. Mr. Gupta (W)

CM245. Molecular Biotechnology for Engineers. (4) (Formerly numbered Biomedical Engineering CM245.) (Same as Chemical Engineering CM245.) Lecture, four hours; discussion, one hour; outside study, eight hours. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM145. Letter grading. Mr. Liao (F)

C247. Applied Tissue Engineering: Clinical and Industrial Perspective. (4) (Formerly numbered Biomedical Engineering C247.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: course CM202, Chemistry 20A, 20B, 20L, Life Sciences 1 or 2. Overview of central topics of tissue engineering, with focus on how to build artificial tissues into regulated clinically viable products. Topics include biomaterials selection, cell source, delivery methods, FDA approval processes, and physical/chemical and biological testing. Case studies include skin and artificial skin, bone and cartilage, blood vessels, neurotissue engineering, and liver, kidney, and other organs. Clinical and industrial perspectives of tissue engineering products. Manufacturing constraints, clinical limitations, and regulatory challenges in design and development of tissue-engineering devices. Concurrently scheduled with course C147. Letter grading. Mr. Wu (F)

M248. Introduction to Biological Imaging. (4) (Formerly numbered Biomedical Engineering M248.) (Same as Biomedical Physics M248 and Pharmacology M248.) Lecture, three hours; laboratory, one hour; outside study, seven hours. Exploration of role of biological imaging in modern biology and medicine, including imaging physics, instrumentation, image processing, and applications of imaging for range of modalities. Practical experience provided through series of imaging laboratories. Letter grading.

CM250A. Introduction to Micromachining and Microelectromechanical Systems (MEMS). (4) (Formerly numbered Biomedical Engineering CM250A.) (Same as Electrical Engineering CM250A and Mechanical and Aerospace Engineering CM280A.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Introduction to micromachining technologies and microelectromechanical systems (MEMS). Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students design microfabrication processes capable of achieving desired MEMS device. Concurrently scheduled with course CM150. Letter grading. Mr. Judy (W)

M250B. Microelectromechanical Systems (MEMS) Fabrication. (4) (Formerly numbered Biomedical Engineering M250B.) (Same as Electrical Engineering M250B and Mechanical and Aerospace Engineering M280B.) Lecture, three hours; discussion, one hour; outside study, eight hours. Enforced requisite: course CM150 or CM250A. Advanced discussion of micromachining processes used to construct MEMS. Coverage of many lithographic, deposition, and etching processes, as well as their combination in process integration. Materials issues such as chemical resistance, corrosion, mechanical properties, and residual/intrinsic stress. Letter grading. Mr. Judy (Sp)

CM250L. Introduction to Micromachining and Microelectromechanical Systems (MEMS) Laboratory. (2) (Formerly numbered Biomedical Engineering CM250L.) (Same as Electrical Engineering CM250L and Mechanical and Aerospace Engineering CM280L.) Lecture, one hour; laboratory, four hours; outside study, one hour. Requisites: course CM250A, Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Hands-on introduction to micromachining technologies and microelectromechanical systems (MEMS) laboratory. Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students go through process of fabricating MEMS device. Concurrently scheduled with course CM150L. Letter grading. Mr. Judy (F)

M252. Microelectromechanical Systems (MEMS) Device Physics and Design. (4) (Formerly numbered Biomedical Engineering M252.) (Same as Electrical Engineering M252 and Mechanical and Aerospace Engineering M282.) Lecture, four hours; outside study, eight hours. Introduction to MEMS design. Design methods, design rules, sensing and actuation mechanisms, microsensors, and microactuators. Designing MEMS to be produced with both foundry and nonfoundry processes. Computer-aided design for MEMS. Design project required. Letter grading. Mr. Wu (Sp)

257. Engineering Mechanics of Motor Proteins and Cytoskeleton. (4) (Formerly numbered Biomedical Engineering 257.) Lecture, four hours; outside study, eight hours. Requisites: Life Sciences 3, Mathematics 32A, 32B, 33A, 33B, Physics 1A, 1B, 1C. Introduction to physics of motor proteins and cytoskeleton: mass, stiffness and damping of proteins, thermal forces and diffusion, chemical forces, polymer mechanics, structures of cytoskeletal filaments, mechanics of cytoskeleton, polymerization of cytoskeletal filaments, force generation by cytoskeletal filaments, active polymerization, motor protein structure and operation. Emphasis on engineering perspective. Letter grading.

M260. Neuroengineering. (4) (Formerly numbered Biomedical Engineering M260.) (Same as Electrical Engineering M255 and Neuroscience M206.) Lecture, four hours; laboratory, three hours; outside study, five hours. Requisites: Mathematics 32A, Physics 1B or 6B. Introduction to principles and technologies of bioelectricity and neural signal recording, processing, and stimulation. Topics include bioelectricity, electrophysiology (action potentials, local field potentials, EEG, ECOG), intracellular and extracellular recording, microelectrode technology, neural signal processing (neural signal frequency bands, filtering, spike detection, spike sorting, stimulation artifact removal), brain-computer interfaces, deep-brain stimulation, and prosthetics. Letter grading. Mr. Judy (Sp)

M261A-M261B-M261C. Evaluation of Research Literature in Neuroengineering. (2-2-2) (Formerly numbered Biomedical Engineering M261A-M261B-M261C.) (Same as Electrical Engineering M256A-M256B-M256C and Neuroscience M212A-M212B-M212C.) Discussion, two hours; outside study, four hours. Critical discussion and analysis of current literature related to neuroengineering research. S/U grading.

M263. Neuroanatomy: Structure and Function of Nervous System. (4) (Formerly numbered Biomedical Engineering M263.) (Same as Neuroscience M203.) Lecture, three hours; discussion/laboratory, three hours. Anatomy of central and peripheral nervous system at cellular histological and regional systems level, with emphasis on contemporary experimental approaches to morphological study of nervous system in discussions of circuitry and neurochemical anatomy of major brain regions. Consideration of representative vertebrate and invertebrate nervous systems. Letter grading.

C270. Energy-Tissue Interactions. (4) (Formerly numbered Biomedical Engineering C270.) Lecture, three hours; outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life Sciences 3, Physics 17. Introduction to therapeutic and diagnostic use of energy delivery devices in medical and dental applications, with emphasis on understanding fundamental mechanisms underlying various types of energy-tissue interactions. Concurrently scheduled with course C170. Letter grading. Mr. Grundfest (F)

C270L. Introduction to Techniques in Studying Laser-Tissue Interaction. (2) (Formerly numbered Biomedical Engineering C270L.) Laboratory, four hours; outside study, two hours. Corequisite: course C270. Introduction to simulation and experimental techniques used in studying laser-tissue interactions. Topics include computer simulations of light propagation in tissue, measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Concurrently scheduled with course C170L. Letter grading.

C271. Laser-Tissue Interaction II: Biologic Spectroscopy. (4) (Formerly numbered Biomedical Engineering C271.) Lecture, four hours; outside study, eight hours. Requisite: course C270. Designed for physical sciences, life sciences, and engineering majors. Introduction to optical spectroscopy principles, design of spectroscopic measurement devices, optical properties of tissues, and fluorescence spectroscopy biologic media. Concurrently scheduled with course C171. Letter grading. Mr. Grundfest (W)

C272. Design of Minimally Invasive Surgical Tools. (4) (Formerly numbered Biomedical Engineering C272.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, 23L, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Concurrently scheduled with course C172. Letter grading. Mr. Grundfest (F)

CM278. Introduction to Biomaterials. (4) (Formerly numbered Biomedical Engineering CM280.) (Same as Materials Science CM280.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 104. Engineering materials used in medicine and dentistry for repair and/or restoration of damaged natural tissues. Topics include relationships between material properties, suitability to task, surface chemistry, processing and treatment methods, and biocompatibility. Concurrently scheduled with course CM178. Letter grading. Mr. Wu (W)

C279. Biomaterials-Tissue Interactions. (4) (Formerly numbered Biomedical Engineering C281.) Lecture, three hours; outside study, nine hours. Requisite: course CM278. In-depth exploration of host cellular response to biomaterials: vascular response, interface, and clotting, biocompatibility, animal models, inflammation, infection, extracellular matrix, cell adhesion, and role of mechanical forces. Concurrently scheduled with course C179. Letter grading. Mr. Wu (Sp)

282. Biomaterial Interfaces. (4) (Formerly numbered Biomedical Engineering 282.) Lecture, four hours; laboratory, eight hours. Requisite: course CM178 or CM278. Function, utility, and biocompatibility of biomaterials depend critically on their surface and interfacial properties. Discussion of morphology and composition of biomaterials and nanoscales, mesoscales, and macroscales, techniques for characterizing structure and properties of biomaterial interfaces, and methods for designing and fabricating biomaterials with prescribed structure and properties in vitro and in vivo. Letter grading. Ms. Maynard (W)

C283. Targeted Drug Delivery and Controlled Drug Release. (4) (Formerly numbered Biomedical Engineering C283.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Concurrently scheduled with course C183. Letter grading. Ms. Kasko (F)

M284. Functional Neuroimaging: Techniques and Applications. (3) (Formerly numbered Biomedical Engineering M284.) (Same as Biomedical Physics M285, Neuroscience M285, Psychiatry M285, and Psychology M278.) Lecture, three hours. In-depth examination of activation imaging, including MRI and electrophysiological methods, data acquisition and analysis, experimental design, and results obtained thus far in human systems. Strong focus on understanding technologies, how to design activation imaging paradigms, and how to interpret results. Laboratory visits and design and implementation of functional MRI experiment. S/U or letter grading.

C285. Introduction to Tissue Engineering. (4) (Formerly numbered Biomedical Engineering C285.) Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C185. Letter grading. Mr. Wu (Sp)

CM286. Computational Systems Biology: Modeling and Simulation of Biological Systems. (5) (Formerly numbered Biomedical Engineering CM286.) (Same as Computer Science CM286.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Corequisite: Electrical Engineering 102. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM186. Letter grading. Mr. DiStefano (F)

CM287. Thesis Research and Research Communication in Computational and Systems Biology. (2 to 4) (Formerly numbered Biomedical Engineering CM287.) (Same as Computer Science CM287.) Lecture, one hour; discussion, two hours; laboratory, one hour; outside study, eight hours. Requisite: course CM286. Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM187. Letter grading. Mr. DiStefano (Sp)

295A-295Z. Seminars: Research Topics in Bioengineering. (1 to 4) (Formerly numbered Biomedical Engineering 295A-295Z.) Seminar, one to four hours. Limited to bioengineering graduate students. Advanced study and analysis of current topics in bioengineering. Discussion of current research and literature in research specialty of faculty member teaching course. Student presentation of projects in research specialty. May be repeated for credit. S/U grading: 295A. Biomaterial Research. 295B. Biomaterials and Tissue Engineering Research. 295C. Minimally Invasive and Laser Research. 295D. Hybrid Device Research. 295E. Molecular Cell Bioengineering Research. 295F. Biopolymer Materials and Chemistry.

M296A. Advanced Modeling Methodology for Dynamic Biomedical Systems. (4) (Formerly numbered Biomedical Engineering M296A.) (Same as Computer Science M296A and Medicine M270C.) Lecture, four hours; outside study, eight hours. Requisite: Electrical Engineering 141 or 142 or Mathematics 115A or Mechanical and Aerospace Engineering 171A. Development of dynamic systems modeling methodology for physiological, biomedical, pharmacological, chemical, and related systems. Control system, multicompartmental, noncompartmental, and input/output models, linear and nonlinear. Emphasis on model applications, limitations, and relevance in biomedical sciences and other limited data environments. Problem solving in PC laboratory. Letter grading. Mr. DiStefano (F)

M296B. Optimal Parameter Estimation and Experiment Design for Biomedical Systems. (4) (Formerly numbered Biomedical Engineering M296B.) (Same as Biomathematics M270, Computer Science M296B, and Medicine M270D.) Lecture, four hours; outside study, eight hours. Requisite: course CM286 or M296A or Biomathematics 220. Estimation methodology and model parameter estimation algorithms for fitting dynamic system models to biomedical data. Model discrimination methods. Theory and algorithms for designing optimal experiments for developing and quantifying models, with special focus on optimal sampling schedule design for kinetic models. Exploration of PC software for model building and optimal experiment design via applications in physiology and pharmacology. Letter grading. Mr. DiStefano (W)

M296C. Advanced Topics and Research in Biomedical Systems Modeling and Computing. (4) (Formerly numbered Biomedical Engineering M296C.) (Same as Computer Science M296C and Medicine M270E.) Lecture, four hours; outside study, eight hours. Requisite: course M296B. Research techniques and experience on special topics involving models, modeling methods, and model/computing in biological and medical sciences. Review and critique of literature. Research problem searching and formulation. Approaches to solutions. Individual M.S.- and Ph.D.-level project training. Letter grading. Mr. DiStefano (Sp)

M296D. Introduction to Computational Cardiology. (4) (Formerly numbered Biomedical Engineering M296D.) (Same as Computer Science M296D.) Lecture, four hours; outside study, eight hours. Requisite: course CM186. Introduction to mathematical modeling and computer simulation of cardiac electrophysiological process. Ionic models of action potential (AP). Theory of AP propagation in one-dimensional and two-dimensional cardiac tissue. Simulation on sequential and parallel supercomputers, choice of numerical algorithms, to optimize accuracy and to provide computational stability. Letter grading. Mr. Kogan (F,Sp)

298. Special Studies in Bioengineering. (4) (Formerly numbered Biomedical Engineering 298.)Lecture, four hours; outside study, eight hours. Study of selected topics in bioengineering taught by resident and visiting faculty members. May be repeated for credit. Letter grading.

299. Seminar: Bioengineering Topics. (2) (Formerly numbered Biomedical Engineering 299.)Seminar, two hours; outside study, four hours. Designed for graduate bioengineering students. Seminar by leading academic and industrial bioengineers from UCLA, other universities, and bioengineering companies such as Baxter, Amgen, Medtronics, and Guidant on development and application of recent technological advances in discipline. Exploration of cutting-edge developments and challenges in wound healing models, stem cell biology, angiogenesis, signal transduction, gene therapy, cDNA microarray technology, bioartificial cultivation, nano- and micro-hybrid devices, scaffold engineering, and bioinformatics. S/U grading. Mr. Wu (F,W,Sp)

375. Teaching Apprentice Practicum. (4) (Formerly numbered Biomedical Engineering 375.)Seminar, to be arranged. Preparation: apprentice personnel employment as teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of regular faculty member responsible for curriculum and instruction at UCLA. May be repeated for credit. S/U grading.

495. Teaching Assistant Training Seminar. (2) (Formerly numbered Biomedical Engineering 495.)Seminar, two hours; outside study, four hours. Limited to graduate bioengineering students. Required of all departmental teaching assistants. May be taken concurrently while holding TA appointment. Seminar on communicating bioengineering and biomedical engineering principles, concepts, and methods; teaching assistant preparation, organization, and presentation of material, including use of visual aids, grading, advising, and rapport with students. S/U grading. Mr. Kamei (F)

596. Directed Individual or Tutorial Studies. (2 to 8) (Formerly numbered Biomedical Engineering 596.)Tutorial, to be arranged. Limited to graduate bioengineering students. Petition forms to request enrollment may be obtained from program office. Supervised investigation of advanced technical problems. S/U grading.

597A. Preparation for M.S. Comprehensive Examination. (2 to 12) (Formerly numbered Biomedical Engineering 597A.)Tutorial, to be arranged. Limited to graduate bioengineering students. Reading and preparation for M.S. comprehensive examination. S/U grading.

597B. Preparation for Ph.D. Preliminary Examinations. (2 to 16) (Formerly numbered Biomedical Engineering 597B.)Tutorial, to be arranged. Limited to graduate bioengineering students. S/U grading.

597C. Preparation for Ph.D. Oral Qualifying Examination. (2 to 16) (Formerly numbered Biomedical Engineering 597C.)Tutorial, to be arranged. Limited to graduate bioengineering students. Preparation for oral qualifying examination, including preliminary research on dissertation. S/U grading.

598. Research for and Preparation of M.S. Thesis. (2 to 12) (Formerly numbered Biomedical Engineering 598.)Tutorial, to be arranged. Limited to graduate bioengineering students. Supervised independent research for M.S. candidates, including thesis prospectus. S/U grading.

599. Research for and Preparation of Ph.D. Dissertation. (2 to 16) (Formerly numbered Biomedical Engineering 599.)Tutorial, to be arranged. Limited to graduate bioengineering students. Usually taken after students have been advanced to candidacy. S/U grading.