2010-2011 Biomedical Engineering

Interdepartmental Program

UCLA
5121 Engineering V
Box 951600
Los Angeles, CA 90095-1600

 

(310) 794-5945
fax: (310) 794-5956
e-mail: bme@ea.ucla.edu
http://www.bme.ucla.edu

James Dunn, M.D., Ph.D., Chair
 

Faculty Administrative Committee

Denise Aberle, M.D. (Bioengineering, Radiological Sciences)
Alex Bui, Ph.D. (Radiological Sciences)
Mark S. Cohen, Ph.D. (Neurology, Psychiatry and Biobehavioral Sciences, Radiological Sciences)
Timothy J. Deming, Ph.D. (Bioengineering, Chemistry and Biochemistry)
Joseph J. DiStefano III, Ph.D. (Computer Science, Medicine)
James Dunn, M.D., Ph.D. (Bioengineering, Pediatric Surgery)
Chih-Ming Ho, Ph.D. (Bioengineering, Mechanical and Aerospace Engineering)
Jack W. Judy, Ph.D. (Electrical Engineering)
Karen M. Lyons, Ph.D. (Molecular, Cell, and Developmental Biology, Orthopaedic Surgery)
Edward R.B. McCabe, M.D., Ph.D. (Human Genetics, Pediatrics)
Ren Sun, Ph.D. (Molecular and Medical Pharmacology)
Michael A. Teitell, M.D., Ph.D. (Pathology and Laboratory Medicine)
Benjamin M. Wu, D.D.S., Ph.D. (Bioengineering)

Professors

Denise Aberle, M.D. (Bioengineering, Radiological Sciences)
Marvin Bergsneider, M.D. (Neurosurgery)
Francisco Bezanilla, Ph.D. (Physiology)
Douglas L. Black, Ph.D. (Microbiology, Immunology, and Molecular Genetics)
Gregory P. Carman, Ph.D. (Mechanical and Aerospace Engineering)
Tony F.C. Chan, Ph.D. (Mathematics)
Samson Chow, Ph.D. (Molecular and Medical Pharmacology)
Mark S. Cohen, Ph.D. (Neurology, Psychiatry and Biobehavioral Sciences, Radiological Sciences)
Joseph L. Demer, M.D., Ph.D. (Neurology, Ophthalmology)
Linda L. Demer, M.D., Ph.D. (Cardiology, Physiology)
Timothy J. Deming, Ph.D. (Bioengineering, Chemistry and Biochemistry)
Joseph J. DiStefano III, Ph.D. (Computer Science, Medicine)
Bruce S. Dunn, Ph.D. (Materials Science and Engineering)
V. Reggie Edgerton, Ph.D. (Integrative Biology and Physiology)
Alan Garfinkel, Ph.D. (Cardiology, Integrative Biology and Physiology)
Robin L. Garrell, Ph.D. (Chemistry and Biochemistry)
Warren S. Grundfest, M.D. FACS (Bioengineering, Electrical Engineering, Surgery)
Robert P. Gunsalus, Ph.D. (Microbiology, Immunology, and Molecular Genetics)
Vijay Gupta, Ph.D. (Mechanical and Aerospace Engineering)
Chih-Ming Ho, Ph.D. (Mechanical and Aerospace Engineering, Center for Micro Systems Director)
Jack W. Judy, Ph.D. (Electrical Engineering)
Chang-Jin Kim, Ph.D. (Mechanical and Aerospace Engineering)
H. Phillip Koeffler, M.D. (Medicine)
Jody E. Kreiman, Ph.D., in Residence (Surgery)
Elliot M. Landaw, M.D., Ph.D. (Biomathematics)
Daniel S. Levi, M.D., Ph.D. (Pediatrics)
James C. Liao, Ph.D. (Chemical and Biomolecular Engineering)
Edward R.B. McCabe, M.D., Ph.D. (Human Genetics, Pediatrics)
Harry McKellop, Ph.D., in Residence (Orthopaedic Surgery)
Istvan Mody, Ph.D. (Neurology, Physiology)
Harold G. Monbouquette, Ph.D. (Chemical and Biomolecular Engineering)
Samuel S. Murray, M.D., Ph.D. (Medicine)
Peter M. Narins, Ph.D. (Ecology and Evolutionary Biology, Integrative Biology and Physiology)
Ichiro Nishimura, D.D.S., D.M.Sc., D.M.D. (Dentistry)
Michael Sofroniew, M.D., Ph.D. (Neurobiology)
Igor Spigelman, Ph.D. (Dentistry)
Ricky Taira, Ph.D, in Residence (Radiological Sciences)
Michael Teitell, M.D., Ph.D. (Pathology and Laboratory Medicine, Pediatrics)
Albert Thomas, Ph.D., in Residence (Radiological Sciences)
Paul M. Thompson, Ph.D., in Residence (Neurology)
James G. Tidball, Ph.D. (Integrative Biology and Physiology)
Kang Ting, D.M.D., D.M.Sc. (Dentistry)
Arthur Toga, Ph.D. (Neurology)
Jeffrey Wang, M.D. (Orthopaedic Surgery)
David Wong, Ph.D. (Dentistry)
Hong Zhou, Ph.D. (Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute)

Professor Emeriti

Hooshang Kangarloo, M.D. (Pediatrics, Radiological Sciences)

Associate Professors

Alex Bui, Ph.D. (Radiological Sciences)
Katrina Dipple, M.D., Ph.D. (Human Genetics and Pediatrics)
James Dunn, M.D., Ph.D. (Bioengineering, Pediatric Surgery)
Yongho Ju, Ph.D. (Mechanical and Aerospace Engineering)
Daniel T. Kamei, Ph.D. (Bioengineering)
Laurent Pilon, Ph.D. (Mechanical and Aerospace Engineering)
Dario Ringach, Ph.D. (Neurobiology, Psychology)
Jacob Schmidt, Ph.D. (Bioengineering)
Desmond Smith, Ph.D. (Molecular and Medical Pharmacology)
Ren Sun, Ph.D. (Molecular and Medical Pharmacology)
Yi Tang, Ph.D. (Chemical and Biomolecular Engineering)
Peter Tontonoz, M.D., Ph.D. (Pathology and Laboratory Medicine)
Benjamin M. Wu, D.D.S., Ph.D. (Bioengineering, Dentistry, Materials Science and Engineering)
Lily Wu, Ph.D. (Molecular and Medical Pharmacology, Urology)

Assistant Professors

James Bisley, Ph.D. (Neurobiology)
Louis Bouchard, Ph.D. (Chemistry and Biochemistry)
Dino DiCarlo, Ph.D. (Bioengineering)
Christopher Giza, Ph.D. (Surgery, Neurosurgery)
Thomas G. Graeber, Ph.D. (Molecular and Medical Pharmacology)
Xiao Hu, Ph.D., in Residence (Surgery, Neurosurgery)
Andrea M. Kasko, Ph.D. (Bioengineering)
Dejan Markovic, Ph.D. (Electrical Engineering)
Heather Maynard, Ph.D. (Chemistry and Biochemistry)
Aydogan Ozcan, Ph.D. (Electrical Engineering)
Matteo Pellegrini, Ph.D. (Molecular, Cell, and Developmental Biology)
Nader Pouratian, Ph.D. (Neurosurgery)
Tatiana Segura, Ph.D. (Chemical and Biomolecular Engineering)
Landan Shams, Ph.D. (Psychology)
Hsian-Rong Tseng, Ph.D. (Molecular and Medical Pharmacology)
Zhouwen Tu, Ph.D. (Neurology)
R. Michael van Dam, Ph.D. (Molecular and Medical Pharmacology)
Xinshu Xiao, Ph.D. (Integrative Biology and Physiology)

Adjunct Professors

Boris Kogan, Ph.D. (Computer Science)
Howard Winet, Ph.D. (Bioengineering, Orthopaedic Surgery)

Adjunct Associate Professor

Daniel J. Valentino, Ph.D. (Radiological Sciences)

Adjunct Assistant Professor

Bill J. Tawil, M.B.A., Ph.D. (Bioengineering)

Scope and Objectives

The Biomedical Engineering Interdepartmental Program trains specially qualified engineers and scientists to work on engineering applications in either medicine or biotechnology.

Graduates apply engineering principles to current needs and contribute to future advances in the fields of medicine and biotechnology. Fostering careers in industry or academia, the program offers students the choice of an M.S. or Ph.D. degree in eight distinct fields of biomedical engineering.

In addition to selected advanced engineering courses, students are required to take specially designed biomedical engineering courses to ensure a minimal knowledge of the appropriate biological sciences. Students receive practical training via an M.S. or Ph.D. research thesis or dissertation in biomedical engineering. Faculty members have principal appointments in departments across campus and well-equipped laboratories for graduate student research projects.

Graduate Study

For information on graduate admission, see Graduate Programs, page 23.

The following introductory information is based on the 2010-11 edition of Program Requirements for UCLA Graduate Degrees. Complete annual editions of Program Requirements are available at http://www.gdnet.ucla.edu/gasaa/library/pgmrqintro.htm. Students are subject to the detailed degree requirements as published in Program Requirements for the year in which they enter the program.

The Biomedical Engineering Program offers Master of Science (M.S.) and Doctor of Philosophy (Ph.D.) degrees in Biomedical Engineering.

Biomedical Engineering M.S.

Students are expected to complete 42 units, which in most cases include either Biomedical Engineering C201, CM202, and CM203, or C204, C205, and C206, and two courses from their area of study. The M.S. degree is offered under both the thesis plan and comprehensive examination plan. Under the thesis plan, 8 units of thesis work may be applied toward the unit requirements for the degree. The comprehensive examination plan consists entirely of coursework (12 courses) and a comprehensive examination. Eight of the 12 courses must be graduate (200-level) courses, and students must maintain a grade-point average of B or better in both upper division and graduate courses. Three Biomedical Engineering 299 courses (6 units total) are also required.

Biomedical Engineering Ph.D.

The Ph.D. program prepares students for advanced study and research in biomedical engineering. The Ph.D. preliminary examination typically consists of both written and oral parts. To receive a pass on the examination, students must receive a pass on both parts. An oral qualifying/advancement to candidacy examination, coursework for two minor fields of study, and defense of the dissertation are also required. The major field consists of six courses, and each minor field consists of three 4-unit courses, of which two must be graduate (200-level) courses. One minor must be in another field of biomedical engineering. Students must maintain a grade-point average of 3.25 or better in all courses.

Fields of Study

Biomaterials, Tissue Engineering, and Biomechanics

Three subfields—biomechanics, biomaterials, and tissue engineering—encompass this broad field. The properties of bone, muscles, and tissues, the replacement of natural materials with artificial compatible and functional materials such as polymer composites, ceramics, and metals, and the complex interactions between implants and the body are studied.

Course Requirements

Core Courses (Required). Biomedical Engineering C201, C204, C205, C206, and two courses from CM240, CM280, C283, C285, Bioengineering 176, Molecular, Cell, and Developmental Biology 100, 104, 138, M140, 165A, 168.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Biomedical Engineering website at http://www.bme.ucla.edu/academics/programs.

Biomedical Instrumentation

The biomedical instrumentation field trains biomedical engineers in the applications and development of instrumentation used in medicine and biotechnology. Examples include the use of lasers in surgery and diagnostics, sensors for detection and monitoring of disease, and microelectromechanical systems (MEMS) devices for controlled drug delivery, surgery, or genetics. The principles underlying each instrument and the specific needs in medical applications are emphasized.

Course Requirements

Core Courses (Required). Biomedical Engineering C201, C204, C205, C206, CM250A, Electrical Engineering 100.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Biomedical Engineering website at http://www.bme.ucla.edu/academics/programs.

Biomedical Signal and Image Processing

The biomedical signal and image processing field encompasses techniques for the acquisition, processing, classification, and analysis of digital biomedical signals, images, and related information, classification and analysis of biomedical data, and decision support of clinical processes. Sample applications include (1) digital imaging research utilizing modalities such as X-ray imaging, computed tomography (CT), and magnetic resonance (MR), positron emission tomography (PET) and SPECT, optical microscopy, and combinations such as PET/MR, (2) signal processing research on hearing to voice recognition to wireless sensors, and (3) bioinformatics research ranging from image segmentation for content-based retrieval from databases to correlating clinical findings with genomic markers. Graduates of the program integrate advanced digital processing and artificial intelligence technologies with healthcare activities and biomedical research. They are prepared for careers involving innovation in the fields of signal processing, medical imaging, and medical-related informatics in either industry or academia.

Course Requirements

Students selecting biomedical signal and image processing as a minor field must take three courses, of which at least two must be graduate (200-level) courses.

Core Courses (Required). Biomedical Engineering C201, CM202, CM203, M214A, Electrical Engineering 113, 211A.

Electives. Biomedical Engineering M248, Biomedical Physics 200A, 200B, M219, 222, Computer Science 143, 161, Electrical Engineering 211B, 214B.

Remedial Courses. Electrical Engineering 102, Program in Computing 10A, 10B.

Biosystem Science and Engineering

Graduate study in biosystem science and engineering is intended for science or engineering students interested in systems biology biosystems or biomedical systems, with an emphasis on systems and integration. This encompasses the systems engineering/cybernetics-based integrative properties or behavior of living systems, including their regulation, control, integration, and intercommunication mechanisms, and their associated measurement, visualization, and mathematical and computer modeling.

The program provides directed interdisciplinary biosystem studies to establish a foundation in system and information science, mathematical modeling, measurement and integrative biosystem science, as well as related specialized life sciences domain studies. It fosters careers in research and teaching in systems biology engineering, medicine, and/or the biomedical sciences, or research and development in the biomedical or pharmaceutical industry. At the system and integration level, biocybernetics methodology is quite broadly applicable to a large spectrum of biomedical problems.

Typical research areas include basic and clinical problems in biomedical systems, systems biology, all types of biocontrol systems, imaging systems, pharmaceutical systems, biotechnology systems, bioinformatics, genomics, neuroscience, and remote sensing systems for the life sciences.

Faculty research areas include computational biology, computational biochemistry, and metabolism; computational cardiology and neuroendocrinology; biomodeling of diseases, cellular processes, metabolic control systems, and gene networks; modeling in genomics, pharmacokinetics, and pharmacodynamics; vision, robotics, speech processing, neuroscience, artificial and real neural network modeling, normative expert systems, wireless remote sensing systems, telemedicine, visualization, and virtual clinical environments.

Course Requirements

Biosystem science and engineering can serve as a minor field for other Ph.D. majors if students complete the following courses with a grade-point average of B+: Biomedical Engineering CM286B, M296A, and one additional graduate-level elective from the additional foundations or electives list.

Core Courses (Required). Biomedical Engineering C201, CM202, CM203, CM286B, CM286C, and either M296A or Biomathematics 220.

Electives. Biomathematics 206, CM208C, M230, Biomedical Engineering M248, CM286C, M296D, Computer Science 161, 170A, 267B, Electrical Engineering 113, 131A, 132A, 141, 142, 211A, 211B, M214A, 214B, 232E, CM250A, M250B, CM250L, M252, 260A, 260B, Mathematics 151A, 151B, 155, 170A, Physics 210B, 231B, Statistics 100A, 100B.

Medical Imaging Informatics

The objective of the medical imaging informatics field is to train students in imaging-based medical informatics. Specifically, the program’s aims are to enable (1) students from engineering backgrounds to become familiar with aspects of clinical and medical environments, such that they are able to appropriately apply their skills and knowledge in these domains, (2) students from medical backgrounds to learn sufficient expertise in current information and engineering technologies to address specific problems within clinical environments, (3) all students to be experts within the field of imaging-based medical informatics, becoming experienced in dealing with diverse biomedical data (imaging and text), and (4) all students to learn to work in a multidisciplinary group of researchers and individuals, enabling new developments within the field.

The underlying goal is to foster a community for students and faculty members from multiple disciplines (represented by individuals from the Schools of Engineering, Education and Information Studies, Medicine, and Public Health) to participate in the growing area of medical imaging informatics.

Course Requirements

Core Courses (Required). Biomedical Engineering 220, 221, 223A, 223B, 223C, 224A, 224B, M226, M227, M228, Human Genetics 210.

Electives. Biomedical Physics 210, 214, Biostatistics 213, M234, 276, Computer Science 217A, 240A, 240B, 241A, 241B, 244A, 245A, 246, 262A, 262B, M262C, 263A, 263B, 265A, 268, M276A, 276B, Electrical Engineering M202B, 211A, 211B, M217, Information Studies 228, 246, 272, 277, Linguistics 218, 232, Neuroscience CM272.

Molecular and Cellular Bioengineering

The field of molecular and cellular bioengineering encompasses the engineering of enzymes, cellular metabolism, biological signal transduction, and cell-cell interactions. Research emphasizes the fundamental basis for diagnosis, disease treatment, and redesign of cellular functions at the molecular level. The field interacts closely with the fields of bioinstrumentation (MEMS), tissue engineering, and neuroengineering. Graduates of the program are targeted principally for employment in academia, in government research laboratories, and in the biotechnology, pharmaceutical, and biomedical industries.

Course Requirements

Core Courses (Required). Biomedical Engineering C201, C204, C205, C206, and two courses from M184, M215, M225, CM245, C283, CM286B, CM286C, Bioengineering 100, Biomathematics 220, M270, M271, Computer Science 170A, Mathematics 146, 151A, Physiological Science 134, Statistics 200B.

Electives. Students are expected to fulfill the remaining course requirements from courses in this group listed on the Biomedical Engineering website at http://www.bme.ucla.edu/academics/programs.

Neuroengineering

The neuroengineering field is a joint endeavor between the Neuroscience Interdepartmental Ph.D. Program in the Geffen School of Medicine and the Biomedical Engineering Interdepartmental Graduate Program in HSSEAS.

The objectives of the neuroengineering field are to enable (1) students with a background in engineering to develop and execute projects that address problems that have a neuroscientific base, (2) students with a background in biological sciences to develop and execute projects that make use of state-of-the-art technology, and (3) all trainees to develop the capacity for the multidisciplinary teamwork that is necessary for new scientific insights and dramatic technological progress. Courses and research projects are cosponsored by faculty members in both HSSEAS and the Brain Research Institute (BRI).

Requisites for Admission. Students entering the neuroengineering program have graduated with undergraduate degrees in engineering, physics, chemistry, or one of the life sciences (for example, biology, microbiology, immunology, and molecular genetics, molecular, cell, and developmental biology, neuroscience, physiology, or psychology). Engineering students must have taken at least one undergraduate course in biology, one course in chemistry, and a year of physics. Students from nonengineering backgrounds are required to have taken courses in undergraduate calculus, differential equations, and linear algebra, in addition to at least a year of undergraduate courses in each of the following: organic chemistry and biochemistry, physics, and biology. Students lacking one or more requisite courses, if they are otherwise admissible, are provided an opportunity for appropriate coursework or tutorial during the summer before they enter the neuroengineering program.

Written Preliminary Examination. The Ph.D. preliminary examination typically consists of three written parts—two in neuroscience and one in neuroengineering. To receive a pass on the examination, students must receive a pass on all parts. Students who fail the examination may repeat it only once, subject to approval of the faculty examination committee.

Students who are in a field other than neuroengineering and who select neuroengineering as a minor must take Biomedical Engineering M260, M263, and Neuroscience 205.

Core Courses (Required). Biomedical Engineering M260, Neuroscience M202, 207, and either Biomedical Engineering M263 or Neuroscience 205.

Electives. During the first and second years, students take at least three courses selected from a menu of new and existing courses.

Biomedical engineering category: Biomedical Engineering C201, M261A, M261B, M261C.

Microelectromechanical systems (MEMS) category: Biomedical Engineering CM250A, Mechanical and Aerospace Engineering CM280L, 284.

Neuroscience category: Neuroscience M201, M273.

Signal processing category: Electrical Engineering 210A, M214A, M217. Remedial courses taken as necessary.

Students without previous exposure to MEMS should take Biomedical Engineering CM150L; those without previous exposure to neuroscience should take Physiological Science 111A; those without previous exposure to signal processing should take Electrical Engineering 102 and113. Both courses are offered every term.

Seminars (First-Year). Two seminars in problem-based approaches to neuroengineering are required. All first-year students take a new graduate seminar series in Winter and Spring Quarters which is co-taught each term by one instructor from HSSEAS and one from the Brain Research Institute. Each seminar introduces students to a single area of neuroengineering and challenges them to develop critical skills in evaluating primary research papers and to design new approaches to current problems. Topics include pattern generation, sensory signal processing, initiation and control of movement, microsensors, neural networks, photonics, and robotics.

Research Seminars. In addition to the formal coursework listed above, all students attend a series of weekly research seminars that allow both students and faculty members to become more conversant with the broad range of subjects in neuro-engineering.

Seminars (Second-Year). All second-year students take a seminar course each term specifically designed for the neuroengineering program. Each course is co-taught by one faculty member from the Brain Research Institute and one from HSSEAS and often include outside UCLA faculty speakers or members of the Industrial Advisory Board.

Lower Division Courses

19. Fiat Lux Freshman Seminars. (1)

Seminar, one hour. Discussion of and critical thinking about topics of current intellectual importance, taught by faculty members in their areas of expertise and illuminating many paths of discovery at UCLA. P/NP grading.

99. Student Research Program. (1 to 2)

Tutorial (supervised research or other scholarly work), three hours per week per unit. Entry-level research for lower division students under guidance of faculty mentor. Students must be in good academic standing and enrolled in minimum of 12 units (excluding this course). Individual contract required; consult Undergraduate Research Center. May be repeated. P/NP grading.

Upper Division Courses

C101. Introduction to Biomedical Engineering. (4)

Lecture, three hours; laboratory, three hours; outside study, six hours. Designed for physical sciences, life sciences, and engineering students. Introduction to wide scope of biomedical engineering via treatment of selected important individual topics by small team of specialists. Concurrently scheduled with course C201. Letter grading. Mr. Kamei (F)

CM102. Basic Human Biology for Biomedical Engineers I. (4)

(Same as Physiological Science CM102.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM202. Letter grading. Mr. Grundfest (F)

CM103. Basic Human Biology for Biomedical Engineers II. (4)

(Same as Physiological Science CM103.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM203. Letter grading. Mr. Grundfest (W)

CM104. Physical Chemistry of Biomacromolecules. (4)

(Same as Bioengineering M104.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Concurrently scheduled with course C204. Letter grading. Ms. Kasko (F)

CM105. Biopolymer Chemistry and Bioconjugates. (4)

(Same as Bioengineering M105.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Concurrently scheduled with course C205. Letter grading. Mr. Deming (W)

CM106. Topics in Biophysics, Channels, and Membranes. (4)

(Same as Bioengineering M106.) Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: Chemistry 20B, Life Sciences 2, 3, 4, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Concurrently scheduled with course C206. Letter grading. Mr. Schmidt (W)

CM131. Nanopore Sensing. (4)

(Same as Bioengineering M131.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Bioengineering 100, 120, Life Sciences 2, 3, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Concurrently scheduled with course C231. Letter grading. Mr. Schmidt (F)

CM140. Introduction to Biomechanics. (4)

(Same as Mechanical and Aerospace Engineering CM140.) Lecture, four hours; discussion, two hours; outside study, six hours. Requisites: Mechanical and Aerospace Engineering 101, 102, 156A. Introduction to mechanical functions of human body; skeletal adaptations to optimize load transfer, mobility, and function. Dynamics and kinematics. Fluid mechanics applications. Heat and mass transfer. Power generation. Laboratory simulations and tests. Concurrently scheduled with course CM240. Letter grading. Mr. Gupta (W)

CM145. Molecular Biotechnology for Engineers. (4)

(Same as Chemical Engineering CM145.) Lecture, four hours; discussion, one hour; outside study, eight hours. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM245. Letter grading. Mr. Liao (F)

CM150. Introduction to Micromachining and Microelectromechanical Systems (MEMS). (4)

(Same as Electrical Engineering CM150 and Mechanical and Aerospace Engineering CM180.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Corequisite: course CM150L. Introduction to micromachining technologies and microelectromechanical systems (MEMS). Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students design microfabrication processes capable of achieving desired MEMS device. Concurrently scheduled with course CM250A. Letter grading. Mr. Judy (F)

CM150L. Introduction to Micromachining and Microelectromechanical Systems (MEMS) Laboratory. (2)

(Same as Electrical Engineering CM150L and Mechanical and Aerospace Engineering CM180L.) Lecture, one hour; laboratory, four hours; outside study, one hour. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Corequisite: course CM150. Hands-on introduction to micromachining technologies and microelectromechanical systems (MEMS) laboratory. Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students go through process of fabricating MEMS device. Concurrently scheduled with course CM250L. Letter grading. Mr. Judy (F)

C170. Energy-Tissue Interactions. (4)

Lecture, three hours; outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life Sciences 3, Physics 17. Corequisite: course C170L. Introduction to therapeutic and diagnostic use of energy delivery devices in medical and dental applications, with emphasis on understanding fundamental mechanisms underlying various types of energy-tissue interactions. Concurrently scheduled with course C270. Letter grading. Mr. Grundfest (F)

C170L. Introduction to Techniques in Studying Laser-Tissue Interaction. (2)

Laboratory, four hours; outside study, two hours. Corequisite: course C170. Introduction to simulation and experimental techniques used in studying laser-tissue interactions. Topics include computer simulations of light propagation in tissue, measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Concurrently scheduled with course C270L. Letter grading.

C171. Laser-Tissue Interaction II: Biologic Spectroscopy. (4)

Lecture, four hours; outside study, eight hours. Requisite: course C170. Designed for physical sciences, life sciences, and engineering majors. Introduction to optical spectroscopy principles, design of spectroscopic measurement devices, optical properties of tissues, and fluorescence spectroscopy biologic media. Concurrently scheduled with course C271. Letter grading. Mr. Grundfest (W)

CM172. Design of Minimally Invasive Surgical Tools. (4)

(Same as Bioengineering M172.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Concurrently scheduled with course C272. Letter grading. Mr. Grundfest (F)

CM180. Introduction to Biomaterials. (4)

(Same as Materials Science CM180.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 104. Engineering materials used in medicine and dentistry for repair and/or restoration of damaged natural tissues. Topics include relationships between material properties, suitability to task, surface chemistry, processing and treatment methods, and biocompatibility. Concurrently scheduled with course CM280. Letter grading. Mr. Wu (W)

C181. Biomaterials-Tissue Interactions. (4)

Lecture, three hours; outside study, nine hours. Requisite: course CM180. In-depth exploration of host cellular response to biomaterials: vascular response, interface, and clotting, biocompatibility, animal models, inflammation, infection, extracellular matrix, cell adhesion, and role of mechanical forces. Concurrently scheduled with course C281. Letter grading. Mr. Wu (Sp)

CM183. Targeted Drug Delivery and Controlled Drug Release. (4)

(Same as Bioengineering M183.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Concurrently scheduled with course C283. Letter grading. Ms. Kasko (F)

M184. Introduction to Computational and Systems Biology. (2)

(Formerly numbered M186A.) (Same as Computational and Systems Biology M184 and Computer Science M184.) Lecture, two hours; outside study, four hours. Requisites: Computer Science 31 (or Program in Computing 10A), Mathematics 31A, 31B. Survey course designed to introduce students to computational and systems modeling and computation in biology and medicine, providing motivation, flavor, culture, and cutting-edge contributions in computational biosciences and aiming for more informed basis for focused studies by students with computational and systems biology interests. Presentations by individual UCLA researchers discussing their active computational and systems biology research. P/NP grading. Mr. DiStefano (W)

C185. Introduction to Tissue Engineering. (4)

Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C285. Letter grading. Mr. Wu (Sp)

CM186B. Computational Systems Biology: Modeling and Simulation of Biological Systems. (5)

(Same as Computational and Systems Biology M186 and Computer Science CM186B.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Corequisite: Electrical Engineering 102. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM286B. Letter grading. Mr. DiStefano (F)

CM186C. Thesis Research and Research Communication in Computational and Systems Biology. (2 to 4)

(Formerly numbered CM186L.) (Same as Computational and Systems Biology M187 and Computer Science CM186C.) Lecture, one hour; discussion, two hours; laboratory, one hour; outside study, eight hours. Requisite: course CM186B. Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM286C. Letter grading. Mr. DiStefano (Sp)

C187. Applied Tissue Engineering: Clinical and Industrial Perspectives. (4)

Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: course CM102, Chemistry 20A, 20B, 20L, Life Sciences 1 or 2. Overview of central topics of tissue engineering, with focus on how to build artificial tissues into regulated clinically viable products. Topics include biomaterials selection, cell source, delivery methods, FDA approval processes, and physical/chemical and biological testing. Case studies include skin and artificial skin, bone and cartilage, blood vessels, neurotissue engineering, and liver, kidney, and other organs. Clinical and industrial perspectives of tissue engineering products. Manufacturing constraints, clinical limitations, and regulatory challenges in design and development of tissue-engineering devices. Concurrently scheduled with course C287. Letter grading. Mr. Wu (F)

188. Special Courses in Biomedical Engineering. (4)

Lecture, four hours; outside study, eight hours. Special topics in biomedical engineering for undergraduate students taught on experimental or temporary basis, such as those taught by resident and visiting faculty members. May be repeated for credit. Letter grading.

Graduate Courses

C201. Introduction to Biomedical Engineering. (4)

Lecture, three hours; laboratory, three hours; outside study, six hours. Designed for physical sciences, life sciences, and engineering students. Introduction to wide scope of biomedical engineering via treatment of selected important individual topics by small team of specialists. Concurrently scheduled with course C101. Letter grading. Mr. Kamei (F)

CM202. Basic Human Biology for Biomedical Engineers I. (4)

(Same as Physiological Science CM204.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM102. Letter grading. Mr. Grundfest (F)

CM203. Basic Human Biology for Biomedical Engineers II. (4)

(Same as Physiological Science CM203.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM103. Letter grading. Mr. Grundfest (W)

C204. Physical Chemistry of Biomacromolecules. (4)

Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Concurrently scheduled with course CM104. Letter grading. Ms. Kasko (F)

C205. Biopolymer Chemistry and Bioconjugates. (4)

Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Concurrently scheduled with course CM105. Letter grading. Mr. Deming (W)

C206. Topics in Biophysics, Channels, and Membranes. (4)

Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: Chemistry 20B, Life Sciences 2, 3, 4, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Concurrently scheduled with course CM106. Letter grading. Mr. Schmidt (W)

M214A. Digital Speech Processing. (4)

(Same as Electrical Engineering M214A.) Lecture, three hours; laboratory, two hours; outside study, seven hours. Requisite: Electrical Engineering 113. Theory and applications of digital processing of speech signals. Mathematical models of human speech production and perception mechanisms, speech analysis/synthesis. Techniques include linear prediction, filter-bank models, and homomorphic filtering. Applications to speech synthesis, automatic recognition, and hearing aids. Letter grading. Ms. Alwan (W)

M215. Biochemical Reaction Engineering. (4)

(Same as Chemical Engineering CM215.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: Chemical Engineering 101C. Use of previously learned concepts of biophysical chemistry, thermodynamics, transport phenomena, and reaction kinetics to develop tools needed for technical design and economic analysis of biological reactors. Letter grading. Mr. Liao (Sp)

M217. Biomedical Imaging. (4)

(Same as Electrical Engineering M217.) Lecture, three hours; outside study, nine hours. Requisite: Electrical Engineering 114 or 211A. Optical imaging modalities in biomedicine. Other nonoptical imaging modalities discussed briefly for comparison purposes. Letter grading.

M219. Principles and Applications of Magnetic Resonance Imaging. (4)

(Same as Biomedical Physics M219.) Lecture, three hours; discussion, one hour. Basic principles of magnetic resonance (MR), physics, and image formation. Emphasis on hardware, Bloch equations, analytic expressions, image contrast mechanisms, spin and gradient echoes, Fourier transform imaging methods, structure of pulse sequences, and various scanning parameters. Introduction to advanced techniques in rapid imaging, quantitative imaging, and spectroscopy. Letter grading.

220. Introduction to Medical Informatics. (2)

Lecture, two hours; outside study, four hours. Designed for graduate students. Introduction to research topics and issues in medical informatics for students new to field. Definition of this emerging field of study, current research efforts, and future directions in research. Key issues in medical informatics to expose students to different application domains, such as information system architectures, data and process modeling, information extraction and representations, information retrieval and visualization, health services research, telemedicine. Emphasis on current research endeavors and applications. S/U grading. Mr. Kangarloo (F)

221. Human Anatomy and Physiology for Medical and Imaging Informatics. (4)

Lecture, four hours; outside study, eight hours. Designed for graduate students. Introduction to basic human anatomy and physiology, with particular emphasis on understanding and visualization of anatomy and physiology through medical images. Topics relevant to acquisition, representation, and dissemination of anatomical knowledge in computerized clinical applications. Topics include chest, cardiac, neurology, gastrointestinal/genitourinary, endocrine, and musculoskeletal systems. Introduction to basic imaging physics (magnetic resonance, computed tomography, ultrasound, computed radiography) to provide context for imaging modalities predominantly used to view human anatomy. Geared toward nonphysicians who require more formal understanding of human anatomy/physiology. Letter grading. Mr. El-Saden (F)

223A-223B-223C. Programming Laboratories for Medical and Imaging Informatics I, II, III. (4-4-4)

Lecture, two hours; laboratory, two hours; outside study, eight hours. Designed for graduate students. Programming laboratories to support coursework in other medical and imaging informatics core curriculum courses. Exposure to programming concepts for medical applications, with focus on basic abstraction techniques used in image processing and medical information system infrastructures. Letter grading. 223A. Requisites: Computer Science 31, 32, Program in Computing 20A, 20B. Course 223A is requisite to 223B, which is requisite to 223C. Integrated with topics presented in course M227 to reinforce concepts presented with practical experience. Projects focus on understanding medical networking issues and implementation of basic protocols for healthcare environment, with emphasis on use of DICOM. Introduction to basic tools and methods used within informatics. 223B. Requisite: course 223A. Integrated with topics presented in courses 223A, M227, and M228 to reinforce concepts presented with practical experience. Projects focus on medical image manipulation and decision support systems. 223C. Requisite: course 223B. Exposure to programming concepts for medical applications, with focus on basic abstraction techniques used to extract meaningful features from medical text and imaging data and visualize results. Integrated with topics presented in courses 224B and M226 to reinforce concepts presented with practical experience. Projects focus on medical information retrieval, knowledge representation, and visualization. Mr. Meng (F,W,Sp)

224A. Physics and Informatics of Medical Imaging. (4)

Lecture, four hours; laboratory, eight hours. Requisites: Mathematics 33A, 33B. Designed for graduate students. Introduction to principles of medical imaging and imaging informatics for nonphysicists. Overview of core imaging modalities: X ray, computed tomography (CT), and magnetic resonance (MR). Topics include signal generation, localization, and quantization. Image representation and analysis techniques such as Markov random fields, spatial characterization (atlases), denoising, energy representations, and clinical imaging workstation design. Provides basic understanding of issues related to basic medical image acquisition and analysis. Current research efforts with focus on clinical applications and new types of information made available through these modalities. Letter grading. Mr. Morioka (W)

224B. Advances in Imaging Informatics. (4)

Lecture, four hours; outside study, eight hours. Requisite: course 224A. Overview of information retrieval techniques in medical imaging and informatics-based applications of imaging, with focus on various advances in field. Introduction to core concepts in information retrieval (IR), reviewing seminal papers on evaluating IR systems and their use in medicine (e.g., teaching files, case-based retrieval, etc.). Medical content-based image retrieval (CBIR) as motivating application, with examination of core works in this area. Techniques to realize medical CBIR, including image feature extraction and processing, feature representation, classification schemes (via machine learning), image indexing, image querying methods, and visualization of images (e.g., perception, presentation). Discussion of more advanced methods now being pursued by researchers. Letter grading. Mr. Morioka (Sp)

M225. Bioseparations and Bioprocess Engineering. (4)

(Same as Chemical Engineering CM225.) Lecture, four hours; discussion, one hour; outside study, seven hours. Corequisite: Chemical Engineering 101C. Separation strategies, unit operations, and economic factors used to design processes for isolating and purifying materials like whole cells, enzymes, food additives, or pharmaceuticals that are products of biological reactors. Letter grading. Mr. Monbouquette (W)

M226. Medical Knowledge Representation. (4)

(Formerly numbered 226.) (Same as Information Studies M253.) Seminar, four hours; outside study, eight hours. Designed for graduate students. Issues related to medical knowledge representation and its application in healthcare processes. Topics include data structures used for representing knowledge (conceptual graphs, frame-based models), different data models for representing spatio-temporal information, rule-based implementations, current statistical methods for discovery of knowledge (data mining, statistical classifiers, and hierarchical classification), and basic information retrieval. Review of work in constructing ontologies, with focus on problems in implementation and definition. Common medical ontologies, coding schemes, and standardized indices/terminologies (SNOMED, UMLS). Letter grading. Mr. Taira (Sp)

M227. Medical Information Infrastructures and Internet Technologies. (4)

(Formerly numbered 227.) (Same as Information Studies M254.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Introduction to networking, communications, and information infrastructures in medical environment. Exposure to basic concepts related to networking at several levels: low-level (TCP/IP, services), medium-level (network topologies), and high-level (distributed computing, Web-based services) implementations. Commonly used medical communication protocols (HL7, DICOM) and current medical information systems (HIS, RIS, PACS). Advances in networking, such as wireless health systems, peer-to-peer topologies, grid/cloud computing. Introduction to security and encryption in networked environments. Letter grading. Mr. Bui (F)

M228. Medical Decision Making. (4)

(Formerly numbered 228.) (Same as Information Studies M255.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Overview of issues related to medical decision making. Introduction to concept of evidence-based medicine and decision processes related to process of care and outcomes. Basic probability and statistics to understand research results and evaluations, and algorithmic methods for decision-making processes (Bayes theorem, decision trees). Study design, hypothesis testing, and estimation. Focus on technical advances in medical decision support systems and expert systems, with review of classic and current research. Introduction to common statistical and decision-making software packages to familiarize students with current tools. Letter grading. Mr. Kangarloo (W)

C231. Nanopore Sensing. (4)

Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Bioengineering 100, 120, Life Sciences 2, 3, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Concurrently scheduled with course CM131. Letter grading. Mr. Schmidt (F)

CM240. Introduction to Biomechanics. (4)

(Same as Mechanical and Aerospace Engineering CM240.) Lecture, four hours; discussion, two hours; outside study, six hours. Requisites: Mechanical and Aerospace Engineering 101, 102, 156A. Introduction to mechanical functions of human body; skeletal adaptations to optimize load transfer, mobility, and function. Dynamics and kinematics. Fluid mechanics applications. Heat and mass transfer. Power generation. Laboratory simulations and tests. Concurrently scheduled with course CM140. Letter grading. Mr. Gupta (W)

CM245. Molecular Biotechnology for Engineers. (4)

(Same as Chemical Engineering CM245.) Lecture, four hours; discussion, one hour; outside study, eight hours. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM145. Letter grading. Mr. Liao (F)

M248. Introduction to Biological Imaging. (4)

(Same as Biomedical Physics M248 and Pharmacology M248.) Lecture, three hours; laboratory, one hour; outside study, seven hours. Exploration of role of biological imaging in modern biology and medicine, including imaging physics, instrumentation, image processing, and applications of imaging for range of modalities. Practical experience provided through series of imaging laboratories. Letter grading.

CM250A. Introduction to Micromachining and Microelectromechanical Systems (MEMS). (4)

(Same as Electrical Engineering CM250A and Mechanical and Aerospace Engineering CM280A.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Corequisite: course CM250L. Introduction to micromachining technologies and microelectromechanical systems (MEMS). Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students design microfabrication processes capable of achieving desired MEMS device. Concurrently scheduled with course CM150. Letter grading. Mr. Judy (W)

M250B. Microelectromechanical Systems (MEMS) Fabrication. (4)

(Same as Electrical Engineering M250B and Mechanical and Aerospace Engineering M280B.) Lecture, three hours; discussion, one hour; outside study, eight hours. Enforced requisite: course CM150 or CM250A. Advanced discussion of micromachining processes used to construct MEMS. Coverage of many lithographic, deposition, and etching processes, as well as their combination in process integration. Materials issues such as chemical resistance, corrosion, mechanical properties, and residual/intrinsic stress. Letter grading. Mr. Judy (Sp)

CM250L. Introduction to Micromachining and Microelectromechanical Systems (MEMS) Laboratory. (2)

(Same as Electrical Engineering CM250L and Mechanical and Aerospace Engineering CM280L.) Lecture, one hour; laboratory, four hours; outside study, one hour. Requisites: Chemistry 20A, 20L, Physics 1A, 1B, 1C, 4AL, 4BL. Corequisite: course CM250A. Hands-on introduction to micromachining technologies and microelectromechanical systems (MEMS) laboratory. Methods of micromachining and how these methods can be used to produce variety of MEMS, including microstructures, microsensors, and microactuators. Students go through process of fabricating MEMS device. Concurrently scheduled with course CM150L. Letter grading. Mr. Judy (F)

M252. Microelectromechanical Systems (MEMS) Device Physics and Design. (4)

(Formerly numbered M250B.) (Same as Electrical Engineering M252 and Mechanical and Aerospace Engineering M282.) Lecture, four hours; outside study, eight hours. Introduction to MEMS design. Design methods, design rules, sensing and actuation mechanisms, microsensors, and microactuators. Designing MEMS to be produced with both foundry and nonfoundry processes. Computer-aided design for MEMS. Design project required. Letter grading. Mr. Wu (Sp)

257. Engineering Mechanics of Motor Proteins and Cytoskeleton. (4)

Lecture, four hours; outside study, eight hours. Requisites: Mathematics 32A, 32B, 33A, 33B, Life Sciences 3, Physics 1A, 1B, 1C. Introduction to physics of motor proteins and cytoskeleton: mass, stiffness and damping of proteins, thermal forces and diffusion, chemical forces, polymer mechanics, structures of cytoskeletal filaments, mechanics of cytoskeleton, polymerization of cytoskeletal filaments, force generation by cytoskeletal filaments, active polymerization, motor protein structure and operation. Emphasis on engineering perspective. Letter grading.

M260. Neuroengineering. (4)

(Same as Electrical Engineering M255 and Neuroscience M206.) Lecture, four hours; laboratory, three hours; outside study, five hours. Requisites: Mathematics 32A, Physics 1B or 6B. Introduction to principles and technologies of bioelectricity and neural signal recording, processing, and stimulation. Topics include bioelectricity, electrophysiology (action potentials, local field potentials, EEG, ECOG), intracellular and extracellular recording, microelectrode technology, neural signal processing (neural signal frequency bands, filtering, spike detection, spike sorting, stimulation artifact removal), brain-computer interfaces, deep-brain stimulation, and prosthetics. Letter grading. Mr. Judy (Sp)

M261A-M261B-M261C. Evaluation of Research Literature in Neuroengineering. (2-2-2)

(Same as Electrical Engineering M256A-M256B-M256C and Neuroscience M212A-M212B-M212C.) Discussion, two hours; outside study, four hours. Critical discussion and analysis of current literature related to neuroengineering research. S/U grading.

M263. Neuroanatomy: Structure and Function of Nervous System. (4)

(Same as Neuroscience M203.) Lecture, three hours; discussion/laboratory, three hours. Anatomy of central and peripheral nervous system at cellular histological and regional systems level, with emphasis on contemporary experimental approaches to morphological study of nervous system in discussions of circuitry and neurochemical anatomy of major brain regions. Consideration of representative vertebrate and invertebrate nervous systems. Letter grading.

C270. Energy-Tissue Interactions. (4)

Lecture, three hours; outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life Sciences 3, Physics 17. Introduction to therapeutic and diagnostic use of energy delivery devices in medical and dental applications, with emphasis on understanding fundamental mechanisms underlying various types of energy-tissue interactions. Concurrently scheduled with course C170. Letter grading. Mr. Grundfest (F)

C270L. Introduction to Techniques in Studying Laser-Tissue Interaction. (2)

Laboratory, four hours; outside study, two hours. Corequisite: course C270. Introduction to simulation and experimental techniques used in studying laser-tissue interactions. Topics include computer simulations of light propagation in tissue, measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Concurrently scheduled with course C170L. Letter grading.

C271. Laser-Tissue Interaction II: Biologic Spectroscopy. (4)

Lecture, four hours; outside study, eight hours. Requisite: course C270. Designed for physical sciences, life sciences, and engineering majors. Introduction to optical spectroscopy principles, design of spectroscopic measurement devices, optical properties of tissues, and fluorescence spectroscopy biologic media. Concurrently scheduled with course C171. Letter grading. Mr. Grundfest (W)

C272. Design of Minimally Invasive Surgical Tools. (4)

Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Concurrently scheduled with course CM172. Letter grading. Mr. Grundfest (F)

CM280. Introduction to Biomaterials. (4)

(Same as Materials Science CM280.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 104. Engineering materials used in medicine and dentistry for repair and/or restoration of damaged natural tissues. Topics include relationships between material properties, suitability to task, surface chemistry, processing and treatment methods, and biocompatibility. Concurrently scheduled with course CM180. Letter grading. Mr. Wu (W)

C281. Biomaterials-Tissue Interactions. (4)

Lecture, three hours; outside study, nine hours. Requisite: course CM280. In-depth exploration of host cellular response to biomaterials: vascular response, interface, and clotting, biocompatibility, animal models, inflammation, infection, extracellular matrix, cell adhesion, and role of mechanical forces. Concurrently scheduled with course C181. Letter grading. Mr. Wu (Sp)

282. Biomaterial Interfaces. (4)

Lecture, four hours; laboratory, eight hours. Requisite: course CM180 or CM280. Function, utility, and biocompatibility of biomaterials depend critically on their surface and interfacial properties. Discussion of morphology and composition of biomaterials and nanoscales, mesoscales, and macroscales, techniques for characterizing structure and properties of biomaterial interfaces, and methods for designing and fabricating biomaterials with prescribed structure and properties in vitro and in vivo. Letter grading. Ms. Maynard (W)

C283. Targeted Drug Delivery and Controlled Drug Release. (4)

Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Concurrently scheduled with course CM183. Letter grading. Ms. Kasko (F)

M284. Functional Neuroimaging: Techniques and Applications. (3)

(Same as Biomedical Physics M285, Neuroscience M285, Psychiatry M285, and Psychology M278.) Lecture, three hours. In-depth examination of activation imaging, including MRI and electrophysiological methods, data acquisition and analysis, experimental design, and results obtained thus far in human systems. Strong focus on understanding technologies, how to design activation imaging paradigms, and how to interpret results. Laboratory visits and design and implementation of functional MRI experiment. S/U or letter grading.

C285. Introduction to Tissue Engineering. (4)

Lecture, three hours; discussion, one hour; outside study, eight hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C185. Letter grading. Mr. Wu (Sp)

CM286B. Computational Systems Biology: Modeling and Simulation of Biological Systems. (5)

(Same as Computer Science CM286B.) Lecture, four hours; laboratory, three hours; outside study, eight hours. Corequisite: Electrical Engineering 102. Dynamic biosystems modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Control system, multicompartmental, predator-prey, pharmacokinetic (PK), pharmacodynamic (PD), and other structural modeling methods applied to life sciences problems at molecular, cellular (biochemical pathways/networks), organ, and organismic levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into mathematics models and implementing them for simulation and analysis. Basics of numerical simulation algorithms, with modeling software exercises in class and PC laboratory assignments. Concurrently scheduled with course CM186B. Letter grading. Mr. DiStefano (F)

CM286C. Thesis Research and Research Communication in Computational and Systems Biology. (2 to 4)

(Formerly numbered CM286L.) (Same as Computer Science CM286C.) Lecture, one hour; discussion, two hours; laboratory, one hour; outside study, eight hours. Requisite: course CM286B. Closely directed, interactive, and real research experience in active quantitative systems biology research laboratory. Direction on how to focus on topics of current interest in scientific community, appropriate to student interests and capabilities. Critiques of oral presentations and written progress reports explain how to proceed with search for research results. Major emphasis on effective research reporting, both oral and written. Concurrently scheduled with course CM186C. Letter grading. Mr. DiStefano (Sp)

C287. Applied Tissue Engineering: Clinical and Industrial Perspectives. (4)

Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: course CM202, Chemistry 20A, 20B, 20L, Life Sciences 1 or 2. Overview of central topics of tissue engineering, with focus on how to build artificial tissues into regulated clinically viable products. Topics include biomaterials selection, cell source, delivery methods, FDA approval processes, and physical/chemical and biological testing. Case studies include skin and artificial skin, bone and cartilage, blood vessels, neurotissue engineering, and liver, kidney, and other organs. Clinical and industrial perspectives of tissue engineering products. Manufacturing constraints, clinical limitations, and regulatory challenges in design and development of tissue-engineering devices. Concurrently scheduled with course C187. Letter grading. Mr. Wu (F)

295A-295Z. Seminars: Research Topics in Biomedical Engineering and Bioengineering. (1 to 4)

Seminar, one to four hours. Limited to biomedical engineering graduate students. Advanced study and analysis of current topics in bioengineering. Discussion of current research and literature in research specialty of faculty member teaching course. Student presentation of projects in research specialty. May be repeated for credit. S/U grading:

295A. Biomaterial Research.

295B. Biomaterials and Tissue Engineering Research.

295C. Minimally Invasive and Laser Research.

295D. Hybrid Device Research.

295E. Molecular Cell Bioengineering Research.

295F. Biopolymer Materials and Chemistry.

M296A. Advanced Modeling Methodology for Dynamic Biomedical Systems. (4)

(Same as Computer Science M296A and Medicine M270C.) Lecture, four hours; outside study, eight hours. Requisite: Electrical Engineering 141 or 142 or Mathematics 115A or Mechanical and Aerospace Engineering 171A. Development of dynamic systems modeling methodology for physiological, biomedical, pharmacological, chemical, and related systems. Control system, multicompartmental, noncompartmental, and input/output models, linear and nonlinear. Emphasis on model applications, limitations, and relevance in biomedical sciences and other limited data environments. Problem solving in PC laboratory. Letter grading. Mr. DiStefano (F)

M296B. Optimal Parameter Estimation and Experiment Design for Biomedical Systems. (4)

(Same as Biomathematics M270, Computer Science M296B, and Medicine M270D.) Lecture, four hours; outside study, eight hours. Requisite: course M296A or Biomathematics 220. Estimation methodology and model parameter estimation algorithms for fitting dynamic system models to biomedical data. Model discrimination methods. Theory and algorithms for designing optimal experiments for developing and quantifying models, with special focus on optimal sampling schedule design for kinetic models. Exploration of PC software for model building and optimal experiment design via applications in physiology and pharmacology. Letter grading. Mr. DiStefano (W)

M296C. Advanced Topics and Research in Biomedical Systems Modeling and Computing. (4)

(Same as Computer Science M296C and Medicine M270E.) Lecture, four hours; outside study, eight hours. Requisite: course M296A. Recommended: course M296B. Research techniques and experience on special topics involving models, modeling methods, and model/computing in biological and medical sciences. Review and critique of literature. Research problem searching and formulation. Approaches to solutions. Individual M.S.- and Ph.D.-level project training. Letter grading. Mr. DiStefano (Sp)

M296D. Introduction to Computational Cardiology. (4)

(Same as Computer Science M296D.) Lecture, four hours; outside study, eight hours. Requisite: course CM186B. Introduction to mathematical modeling and computer simulation of cardiac electrophysiological process. Ionic models of action potential (AP). Theory of AP propagation in one-dimensional and two-dimensional cardiac tissue. Simulation on sequential and parallel supercomputers, choice of numerical algorithms, to optimize accuracy and to provide computational stability. Letter grading. Mr. Kogan (F,Sp)

298. Special Studies in Biomedical Engineering. (4)

Lecture, four hours; outside study, eight hours. Study of selected topics in biomedical engineering taught by resident and visiting faculty members. Letter grading.

299. Seminar: Biomedical Engineering Topics. (2)

Seminar, two hours; outside study, four hours. Designed for graduate biomedical engineering students. Seminar by leading academic and industrial biomedical engineers from UCLA, other universities, and biomedical engineering companies such as Baxter, Amgen, Medtronics, and Guidant on development and application of recent technological advances in discipline. Exploration of cutting-edge developments and challenges in wound healing models, stem cell biology, angiogenesis, signal transduction, gene therapy, cDNA microarray technology, bioartificial cultivation, nano- and micro-hybrid devices, scaffold engineering, and bioinformatics. S/U grading. Mr. Wu (F,W,Sp)

375. Teaching Apprentice Practicum. (4)

Seminar, to be arranged. Preparation: apprentice personnel employment as teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of regular faculty member responsible for curriculum and instruction at UCLA. May be repeated for credit. S/U grading.

495. Teaching Assistant Training Seminar. (2)

Seminar, two hours; outside study, four hours. Limited to graduate biomedical engineering students. Required of all departmental teaching assistants. May be taken concurrently while holding TA appointment. Seminar on communicating bioengineering and biomedical engineering principles, concepts, and methods; teaching assistant preparation, organization, and presentation of material, including use of visual aids, grading, advising, and rapport with students. S/U grading. Mr. Kamei (F)

596. Directed Individual or Tutorial Studies. (2 to 8)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. Petition forms to request enrollment may be obtained from program office. Supervised investigation of advanced technical problems. S/U grading.

597A. Preparation for M.S. Comprehensive Examination. (2 to 12)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. Reading and preparation for M.S. comprehensive examination. S/U grading.

597B. Preparation for Ph.D. Preliminary Examinations. (2 to 16)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. S/U grading.

597C. Preparation for Ph.D. Oral Qualifying Examination. (2 to 16)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. Preparation for oral qualifying examination, including preliminary research on dissertation. S/U grading.

598. Research for and Preparation of M.S. Thesis. (2 to 12)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. Supervised independent research for M.S. candidates, including thesis prospectus. S/U grading.

599. Research for and Preparation of Ph.D. Dissertation. (2 to 16)

Tutorial, to be arranged. Limited to graduate biomedical engineering students. Usually taken after students have been advanced to candidacy. S/U grading.