C201. Introduction to Biomedical Engineering. (4)
Lecture, three hours; laboratory, three hours; outside study, six hours. Designed for physical sciences, life sciences, and engineering students. Introduction to wide scope of biomedical engineering via treatment of selected important individual topics by small team of specialists. Concurrently scheduled with course C101. Letter grading. Mr. Kabo (F)
CM202. Basic Human Biology for Biomedical Engineers I. (4)
(Same as Physiological Science CM204.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM102. Letter grading. Mr. Montemagno (F)
CM203. Basic Human Biology for Biomedical Engineers II. (4)
(Same as Physiological Science CM203.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM103. Letter grading. Mr. Montemagno (W)
M214A. Digital Speech Processing. (4)
(Same as Electrical Engineering M214A.) Lecture, three hours; laboratory, two hours; outside study, seven hours. Requisite: Electrical Engineering 113. Theory and applications of digital processing of speech signals. Mathematical models of human speech production and perception mechanisms, speech analysis/synthesis. Techniques include linear prediction, filter-bank models, and homomorphic filtering. Applications to speech synthesis, automatic recognition, and hearing aids. Letter grading. Ms. Alwan (W)
M215. Biochemical Reaction Engineering. (4)
(Same as Chemical Engineering CM215.) Lecture, four hours; outside study, eight hours. Requisites: Chemical Engineering 101C and 106, or Chemistry 156. Use of previously learned concepts of biophysical chemistry, thermodynamics, transport phenomena, and reaction kinetics to develop tools needed for technical design and economic analysis of biological reactors. Letter grading. Mr. Liao (Sp)
(Same as Electrical Engineering M217.) Lecture, three hours; laboratory, two hours; outside study, seven hours. Requisite: Electrical Engineering 114D or 211A. Mathematical principles of medical imaging modalities: X-ray, computed tomography, positron emission tomography, single photon emission computed tomography, magnetic resonance imaging. Topics include basic principles of each imaging system, image reconstruction algorithms, system configurations and their effects on reconstruction algorithms, specialized imaging techniques for specific applications such as flow imaging. Letter grading.
M225. Bioseparations and Bioprocess Engineering. (4)
(Same as Chemical Engineering CM225.) Lecture, four hours; outside study, eight hours. Requisites: Chemical Engineering 101C and 103, or Chemistry 156. Separation strategies, unit operations, and economic factors used to design processes for isolating and purifying materials like whole cells, enzymes, food additives, or pharmaceuticals that are products of biological reactors. Letter grading. Mr. Monbouquette (W)
230. Engineering Principles of Ultrasound. (4)
Lecture, three hours; discussion, one hour; outside study, eight hours. Introduction to science and technology of acoustics in biological systems, starting with physical acoustics, acoustic wave (Helmholtz) equation, acoustic propagation and scattering in homogeneous and inhomogeneous media, and acoustic attentuation and davitation phenomena. Acoustic impedance, equivalent circuits, and network models. Electroacoustic transducers (piezoelectric and MEMS) and radiators. Acoustic generation, modulation, and pulse forming. Acoustic noise mechanisms. Receiving and processing of acoustic waves in presence of noise. Letter grading. Mr. Brown (F)
CM240. Introduction to Biomechanics. (4)
(Same as Mechanical and Aerospace Engineering CM240.) Lecture, four hours; outside study, eight hours. Requisites: Civil Engineering 108 or Mechanical and Aerospace Engineering 102, 156A. Introduction to mechanical functions of human body; skeletal adaptations to optimize load transfer, mobility, and function. Dynamics and kinematics. Fluid mechanics applications. Heat and mass transfer. Power generation. Laboratory simulations and tests. Concurrently scheduled with course CM140. Letter grading. Mr. Gupta (W)
C241L. Biomechanics Laboratory. (4)
Lecture, one hour; laboratory, three hours; outside study, eight hours. Requisite: course CM140 or Mechanical and Aerospace Engineering 156A. Hands-on laboratory pertaining to mechanical testing and analysis of long bone specimens. Students, working in pairs, engage in all aspects of procedures. Fundamentals include design and fabrication of signal processing circuitry for use in data acquisition process, including bridge completion circuits, amplifiers, and passive filters; computerized data acquisition using Lab View and A/D input/output (I/O) board; strain measurements on metallic and bone specimens. Finite element analysis of structure under investigation; comparison of experimental, theoretical, and computational results. Concurrently scheduled with course C141L. Letter grading.
CM245. Molecular Biotechnology for Engineers. (4)
(Same as Chemical Engineering CM245.) Lecture, four hours; discussion, one hour; outside study, eight hours. Selected topics in molecular biology that form foundation of biotechnology and biomedical industry today. Topics include recombinant DNA technology, molecular research tools, manipulation of gene expression, directed mutagenesis and protein engineering, DNA-based diagnostics and DNA microarrays, antibody and protein-based diagnostics, genomics and bioinformatics, isolation of human genes, gene therapy, and tissue engineering. Concurrently scheduled with course CM145. Letter grading. Mr. Liao (F)
M248. Introduction to Biological Imaging. (4)
(Same as Biomedical Physics M248 and Pharmacology M248.) Lecture, three hours; laboratory, one hour; outside study, seven hours. Exploration of role of biological imaging in modern biology and medicine, including imaging physics, instrumentation, image processing, and applications of imaging for a range of modalities. Practical experience provided through a series of imaging laboratories. Letter grading.
M250A. Microelectromechanical Systems (MEMS) Fabrication. (4)
(Same as Electrical Engineering M250A and Mechanical and Aerospace Engineering M280.) Lecture, three hours; discussion, one hour; outside study, eight hours. Requisite: course M150L. Advanced discussion of micromachining processes used to construct MEMS. Coverage of many lithographic, deposition, and etching processes, as well as their combination in process integration. Materials issues such as chemical resistance, corrosion, mechanical properties, and residual/intrinsic stress. Letter grading. Mr. Judy (W)
M250B. Microelectromechanical Systems (MEMS) Device Physics and Design. (4)
(Same as Electrical Engineering M250B and Mechanical and Aerospace Engineering M282.) Lecture, three hours; discussion, one hour; outside study, eight hours. Requisite: course M250A. Introduction to MEMS design. Design methods, design rules, sensing and actuation mechanisms, microsensors, and microactuators. Designing MEMS to be produced with both foundry and nonfoundry processes. Computer-aided design for MEMS. Design project required. Letter grading.
Mr. Wu (Sp)
C251. Nanofabrication of Biomedical Systems Using Nonconventional Materials. (4)
Lecture, four hours; outside study, eight hours. Requisites: course M150L (or Electrical Engineering M150L), M250B. Use of nontraditional substrates and materials in fabrication of biomedical nanosystems. Materials and fabrication issues, post-processing integration, compatibility with standard processes, and standard fabrication environment. Packaging concerns. Imaging and diagnostics techniques. Reliability issues. Concurrently scheduled with course C151. Letter grading. Mr. Montemagno (W)
257. Engineering Mechanics of Motor Proteins and Cytoskeleton. (4)
Lecture, four hours; outside study, eight hours. Requisites: Mathematics 32A, 32B, 33A, 33B, Life Sciences 3, Physics 1A, 1B, 1C. Introduction to physics of motor proteins and cytoskeleton: mass, stiffness and damping of proteins, thermal forces and diffusion, chemical forces, polymer mechanics, structures of cytoskeletal filaments, mechanics of cytoskeleton, polymerization of cytoskeletal filaments, force generation by cytoskeletal filaments, active polymerization, motor protein structure and operation. Emphasis on engineering perspective. Letter grading. Mr. Montemagno (Sp)
M259H. Biomechanics of Traumatic Injury. (4)
(Same as Environmental Health Sciences M259H.) Lecture, four hours; outside study, eight hours. Designed for graduate students. Introduction to applied biomechanics of accidental injury causation and prevention; discussion of mechanisms of injury that result in bone and soft tissue trauma; discussion of mechanisms of healing for effective rehabilitation after traumatic injury. Letter grading. Mr. Liu (W)
(Formerly numbered 260.) (Same as Neuroscience M206.) Lecture, four hours; laboratory, three hours. Requisites: Mathematics 32A, Molecular, Cell, and Developmental Biology 100, 171. Introduction to principles and technologies of neural recording and stimulation. Neurophysiology; clinical electrophysiology (EEG, evoked potentials, inverse problem, preoperative brain recording), extracellular microelectrodes and recording (field potentials and single units), chronic recording with extracellular electrodes; electrode biocompatibility, tissue damage, electrode and cable survival; intracellular recording and glass pipettes electrodes, iontophoresis; imaging neural activity (Ca imaging, voltage-sensitive dyes), intrinsic optical imaging; MRI, fMRI. Letter grading. Mr. Judy (Sp)
M261A-M261B-M261C. Evaluation of Research Literature in Neuroengineering. (2-2-2)
(Same as Neuroscience M212A-M212B-M212C.) Discussion, two hours. Critical discussion and analysis of current literature related to neuroengineering research. S/U grading.
M263A-M263B. Organization of Neural Systems. (4-4)
(Same as Neuroscience M203A-M203B.) Lecture, three hours; discussion/laboratory, three hours. Integration of neuroanatomical and systems-level functional analysis of neural circuits leading to appreciation of their emergent properties. Discussion of organization of vertebrate central and peripheral nervous system based on cellular histological and regional analysis, highlighting contemporary experimental approaches. Topics include sensory processing, motor systems, physiological regulation, drive, learning, and neural basis of cognition. In Progress and letter grading.
C270. Energy-Tissue Interactions. (4)
Lecture, three hours; outside study, nine hours. Requisites: Electrical Engineering 172, 175, Life Sciences 3, Physics 17. Introduction to therapeutic and diagnostic use of energy delivery devices in medical and dental applications, with emphasis on understanding fundamental mechanisms underlying various types of energy-tissue interactions. Concurrently scheduled with course C170. Letter grading. Mr. Grundfest (F)
C270L. Introduction to Techniques in Studying Laser-Tissue Interaction. (2)
Laboratory, four hours; outside study, two hours. Corequisite: course C270. Introduction to simulation and experimental techniques used in studying laser-tissue interactions. Topics include computer simulations of light propagation in tissue, measuring absorption spectra of tissue/tissue phantoms, making tissue phantoms, determination of optical properties of different tissues, techniques of temperature distribution measurements. Concurrently scheduled with course C170L. Letter grading.
C271. Laser-Tissue Interaction II: Biologic Spectroscopy. (4)
Lecture, four hours; outside study, eight hours. Requisite: course C270. Designed for physical sciences, life sciences, and engineering majors. Introduction to optical spectroscopy principles, design of spectroscopic measurement devices, optical properties of tissues, and fluorescence spectroscopy biologic media. Concurrently scheduled with course C171. Letter grading. Mr. Grundfest (W)
CM280. Introduction to Biomaterials. (4)
(Same as Materials Science CM280.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, and 20L, or Materials Science 14. Engineering materials used in medicine and dentistry for repair and/or restoration of damaged natural tissues. Topics include relationships between material properties, suitability to task, surface chemistry, processing and treatment methods, and biocompatibility. Concurrently scheduled with course CM180. Letter grading. Mr. Wu (W)
C281. Biomaterials-Tissue Interactions. (4)
Lecture, three hours; outside study, nine hours. Requisite: course CM280. In-depth exploration of host cellular response to biomaterials: vascular response, interface, and clotting, biocompatibility, animal models, inflammation, infection, extracellular matrix, cell adhesion, and role of mechanical forces. Concurrently scheduled with course C181. Letter grading. Mr. Wu (Sp)
282. Biomaterial Interfaces. (4)
Lecture, four hours; laboratory, eight hours. Requisite: course CM180 or CM280. Function, utility, and biocompatibility of biomaterials depend critically on their surface and interfacial properties. Discussion of morphology and composition of biomaterials and nanoscales, mesoscales, and macroscales, techniques for characterizing structure and properties of biomaterial interfaces, and methods for designing and fabricating biomaterials with prescribed structure and properties in vitro and in vivo. Letter grading. Ms. Maynard (W)
C285. Introduction to Tissue Engineering. (4)
Lecture, three hours; outside study, nine hours. Requisites: course CM102 or CM202, Chemistry 20A, 20B, 20L. Tissue engineering applies principles of biology and physical sciences with engineering approach to regenerate tissues and organs. Guiding principles for proper selection of three basic components for tissue engineering: cells, scaffolds, and molecular signals. Concurrently scheduled with course C185. Letter grading. Mr. Wu (Sp)
295A-295Z. Seminars: Research Topics in Biomedical Engineering and Bioengineering. (1 to 4)
Seminar, one to four hours. Limited to biomedical engineering graduate students. Advanced study and analysis of current topics in bioengineering. Discussion of current research and literature in research specialty of faculty member teaching course. Student presentation of projects in research specialty. May be repeated for credit. S/U grading:
295A. Nanotechnology Research.
295B. Biomaterials and Tissue Engineering Research.
295C. Minimally Invasive and Laser Research.
M296A. Advanced Modeling Methodology for Dynamic Biomedical Systems. (4)
(Same as Computer Science M296A and Medicine M270C.) Lecture, four hours; outside study, eight hours. Requisite: Electrical Engineering 141 or 142 or Mathematics 115A or Mechanical and Aerospace Engineering 171A. Development of dynamic systems modeling methodology for physiological, biomedical, pharmacological, chemical, and related systems. Control system, multicompartmental, noncompartmental, and input/output models, linear and nonlinear. Emphasis on model applications, limitations, and relevance in biomedical sciences and other limited data environments. Problem solving in PC laboratory. Letter grading. Mr. DiStefano (F)
M296B. Optimal Parameter Estimation and Experiment Design for Biomedical Systems. (4)
(Same as Biomathematics M270, Computer Science M296B, and Medicine M270D.) Lecture, four hours; outside study, eight hours. Requisite: course M296A or Biomathematics 220. Estimation methodology and model parameter estimation algorithms for fitting dynamic system models to biomedical data. Model discrimination methods. Theory and algorithms for designing optimal experiments for developing and quantifying models, with special focus on optimal sampling schedule design for kinetic models. Exploration of PC software for model building and optimal experiment design via applications in physiology and pharmacology. Letter grading. Mr. DiStefano (W)
M296C. Advanced Topics and Research in Biomedical Systems Modeling and Computing. (4)
(Same as Computer Science M296C and Medicine M270E.) Lecture, four hours; outside study, eight hours. Requisite: course M296A. Recommended: course M296B. Research techniques and experience on special topics involving models, modeling methods, and model/computing in biological and medical sciences. Review and critique of literature. Research problem searching and formulation. Approaches to solutions. Individual M.S.- and Ph.D.-level project training. Letter grading. Mr. DiStefano (Sp)
M296D. Introduction to Computational Cardiology. (4)
(Same as Computer Science M296D.) Lecture, four hours; outside study, eight hours. Requisite: course M196B. Introduction to mathematical modeling and computer simulation of cardiac electrophysiological process. Ionic models of action potential (AP). Theory of AP propagation in 1D and 2D cardiac tissue. Simulation on sequential and parallel supercomputers, choice of numerical algorithms, to optimize accuracy and to provide computational stability. Letter grading. Mr. Kogan (F,Sp)
CM296L. Biomedical Systems/Biocybernetics Research Laboratory. (2 to 4)
(Same as Computer Science CM296L.) Lecture, two hours; laboratory, two hours. Requisite: course M196B. Special laboratory techniques and experience in biocybernetics research. Laboratory instruments, their use, design, and/or modification for research in life sciences. Special research hardware, firmware, software. Use of simulation in experimental laboratory. Laboratory automation and safety. Comprehensive experiment design. Radioactive isotopes and kinetic studies. Experimental animals, controls. Concurrently scheduled with course CM196L. Letter grading. Mr. DiStefano
298. Special Studies in Biomedical Engineering. (4)
Lecture, four hours; outside study, eight hours. Study of selected topics in biomedical engineering taught by resident and visiting faculty members. Letter grading.
299. Seminar: Biomedical Engineering Topics. (2)
Seminar, two hours; outside study, four hours. Designed for graduate biomedical engineering students. Seminar by leading academic and industrial biomedical engineers from UCLA, other universities, and biomedical engineering companies such as Baxter, Amgen, Medtronics, and Guidant on development and application of recent technological advances in the discipline. Exploration of cutting-edge developments and challenges in wound healing models, stem cell biology, angiogenesis, signal transduction, gene therapy, cDNA microarray technology, bioartificial cultivation, nano- and micro-hybrid devices, scaffold engineering, and bioinformatics. S/U grading. Mr. Wu (F,W,Sp)
375. Teaching Apprentice Practicum. (4)
Seminar, to be arranged. Preparation: apprentice personnel employment as a teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of a regular faculty member responsible for curriculum and instruction at the University. May be repeated for credit. S/U grading.
596. Directed Individual or Tutorial Studies. (2 to 8)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. Petition forms to request enrollment may be obtained from program office. Supervised investigation of advanced technical problems. S/U grading.
597A. Preparation for M.S. Comprehensive Examination. (2 to 12)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. Reading and preparation for M.S. comprehensive examination. S/U grading.
597B. Preparation for Ph.D. Preliminary Examinations. (2 to 16)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. S/U grading.
597C. Preparation for Ph.D. Oral Qualifying Examination. (2 to 16)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. Preparation for oral qualifying examination, including preliminary research on dissertation. S/U grading.
598. Research for and Preparation of M.S. Thesis. (2 to 12)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. Supervised independent research for M.S. candidates, including thesis prospectus. S/U grading.
599. Research for and Preparation of Ph.D. Dissertation. (2 to 16)
Tutorial, to be arranged. Limited to graduate biomedical engineering students. Usually taken after students have been advanced to candidacy. S/U grading.