UCLA
5121 Engineering V
Box 951600
Los Angeles, CA 90095-1600
(310) 267-4985
fax: (310) 794-5956
e-mail: bioeng@ea.ucla.edu
http://www.bioeng.ucla.edu
Benjamin M. Wu, D.D.S., Ph.D., Chair
Daniel T. Kamei, Ph.D., Vice Chair
Mark S. Cohen, Ph.D., in Residence
Warren S. Grundfest, M.D., FACS
Chih-Ming Ho, Ph.D. (Ben Rich Lockheed Martin Professor of Aeronautics)
Edward R.B. McCabe, M.D., Ph.D. (Mattel Executive Endowed Professor Emeritus of Pediatrics)
Faculty members in the Department of Bioengineering believe that the interface between biology and the physical sciences represents an exciting area for science in the twenty-first century. Bioengineering has established itself as an independent field and engineering discipline, resulting in the formation of many new bioengineering departments and the redefinition of established programs. Faculty members have embraced this unique opportunity by developing an innovative curriculum, creating state-of-the-art facilities, and performing cutting-edge research.
Instead of treating bioengineering as an application of traditional engineering, it is taught as an applied science discipline in its own right. The bioengineering program is a structured compilation of unique forward-looking courses dedicated to producing graduates who are well-grounded in the fundamental sciences and highly proficient in rigorous analytical engineering tools necessary for lifelong success in the wide range of possible bioengineering careers. The program provides a unique engineering educational experience that responds to the growing needs and demands of bioengineering.
Bioengineering is a diverse multidisciplinary field that has established itself as an independent engineering discipline. The school has developed an innovative Bioengineering Department that is dedicated to producing graduates who are well-grounded in fundamental sciences and the rigorous analytical engineering tools necessary for lifelong success in the many possible bioengineering careers.
Undergraduate Program Objectives
The goal of the bioengineering curriculum is to train future leaders by providing students with the fundamental scientific knowledge and engineering tools necessary for graduate study in engineering or scientific disciplines, continued education in health professional schools, or employment in industry. There are six main objectives: to provide students with (1) rigorous training in engineering and fundamental sciences, (2) education in social and ethical issues, (3) knowledge and experience in state-of-the-art research in bioengineering, (4) experience in oral and written communications, (5) problem-solving and team-building skills to succeed in a career in bioengineering, and (6) information to help them continue lifelong learning as the diverse, interdisciplinary field of bioengineering evolves.
The Bioengineering major is a designated capstone major. Utilizing knowledge from previous courses and new techniques learned from the capstone courses, undergraduate students work in teams to apply advanced knowledge of mathematics, science, and engineering principles to address problems at the interface of biology and engineering and to develop innovative bioengineering solutions to meet specific sets of design criteria. Coursework entails construction of student designs, project updates, presentation of projects in written and oral format, and team competition.
Required: Bioengineering 10; Chemistry and Biochemistry 20A, 20B, 20L, 30A, 30AL, 30B, 30BL; Computer Science 31; Life Sciences 2 (satisfies HSSEAS GE life sciences requirement), 3, 4, 23L; Mathematics 31A, 31B, 32A, 32B, 33A, 33B; Physics 1A, 1B, 1C, 4AL, 4BL.
Required: Bioengineering 100, M106, 110, 120, 165EW (or Engineering 183EW or 185EW), 167L, 176, 180, Chemistry and Biochemistry 153A, Electrical Engineering 100; three technical breadth courses (12 units) selected from an approved list available in the Office of Academic and Student Affairs; two capstone design courses (Bioengineering 177A, 177B); and three major field elective courses (12 units) from Bioengineering M104, M105, M131, 180L, 181, 181L, 199 (8 units maximum), Biomedical Engineering C101, CM102, CM103, CM140, CM145, C147, CM150, CM150L, C170, C171, CM180, C181, CM183, C185, CM186, CM187.
The three technical breadth and three major field elective courses may also be selected from one of the following tracks. Bioengineering majors cannot take bioengineering technical breadth courses to fulfill the technical breadth requirement.
Biomaterials and Regenerative Medicine: Bioengineering M104, M105, 199 (8 units maximum), Biomedical Engineering CM140, C147, CM183, C185, Chemistry and Biochemistry C140, C181, Materials Science and Engineering 104, 110, 111, 120, 130, 132, 140, 143A, 150, 151, 160, 161, Molecular, Cell, and Developmental Biology 168. The above materials science and engineering courses may be used to satisfy the technical breadth requirement.
Biomedical Devices: Bioengineering M131, 199 (8 units maximum), Biomedical Engineering CM172, Electrical Engineering 102, CM150 (or Mechanical and Aerospace Engineering CM180), CM150L (or Mechanical and Aerospace Engineering CM180L), Mechanical and Aerospace Engineering C187L. The electrical engineering or mechanical and aerospace engineering courses listed above may be used to satisfy the technical breadth requirement.
For Bioengineering 199 to fulfill a track requirement, the research project must fit within the scope of the track field, and the research report must be approved by the supervisor and vice chair.
For information on University and general education requirements, see Requirements for B.S. Degrees on page 20 or http://www.registrar.ucla.edu/ge/.
Although the graduate program in bioengineering is currently being developed, individuals who would like to conduct research in the laboratories of the professors in the Bioengineering Department should apply to the graduate program in the Biomedical Engineering Interdepartmental Program (http://www.bme.ucla.edu).
Denise Aberle, M.D. (Kansas, 1979)
Medical imaging informatics: imaging-based clinical trials, medical data visualization
Mark S. Cohen, Ph.D. (Rockefeller, 1985)
Rapid methods of MR imaging, fusion of electrophyisology and fMRI, advanced approaches to MR data analysis, ultra-low field MRI using SQUID detection, low energy focused ultrasound for neurostimulation
Timothy J. Deming, Ph.D. (UC Berkeley, 1993)
Polymer synthesis, polymer processing, supramolecular materials, organometallic catalysis, biomimetic materials, polypeptides
James Dunn, M.D., Ph.D. (Harvard, MIT, 1992)
Tissue engineering, stem cell therapy, regenerative medicine
Warren S. Grundfest, M.D., FACS (Columbia, 1980)
Excimer laser, minimally invasive surgery, biological spectroscopy
Chih-Ming Ho, Ph.D. (Johns Hopkins, 1974)
Molecular mechanics, nanofluidics, and bio-nano research
Gerald C.L. Wong, Ph.D. (UC Berkeley, 1994)
Antimicrobials and antibiotic-resistant pathogens, bacterial communities, cystic fibrosis, apoptosis proteins and cancer therapeutics, disinfection and water purification, self-assembly in biology and biotechnology, physical chemistry of solvation, soft condensed matter physics, biophysics
Benjamin M. Wu, D.D.S. (U. Pacific, 1987), Ph.D. (MIT, 1997)
Biomaterials, cell-material interactions, materials processing, tissue engineering, prosthetic and regenerative dentistry
Hooshang Kangarloo, M.D. (Tehran, 1970)
Telemedicine, healthcare process modeling and evaluation, and imaging informatics
Edward R.B. McCabe, Ph.D. (USC, 1972), M.D. (USC, 1974)
Stem cell identification, regenerative medicine, systems biology
Daniel T. Kamei, Ph.D. (MIT, 2001)
Molecular cell bioengineering, rational design of molecular therapeutics, systems-level analyses of cellular processes, drug delivery, diagnostics
Jacob J. Schmidt, Ph.D. (Minnesota, 1999)
Bioengineering and biophysics at micro and nanoscales, membrane protein engineering, biological-inorganic hybrid devices
Dino Di Carlo, Ph.D. (UC Berkeley, 2006)
Microfluidics, biomedical microdevices, cellular diagnostics, cell analysis and engineering
Andrea M. Kasko, Ph.D. (U. Akron, 2004)
Polymer synthesis, biomaterials, tissue engineering, cell-material interactions
Debiao Li, Ph.D. (U. Virginia, 1992)
Development and clinical application of fast MR imaging techniques for the evaluation of the cardiovascular system
Kayvan Niazi, Ph.D. (UCLA, 2000)
Molecular and cellular bioengineering, immunotherapeutics
Shahrooz Rabizadeh, Ph.D. (UCLA, 1999)
Molecular and cellular bioengineering, drug discovery in cancer and neurodegeneration
Bill J. Tawil, M.B.A. (Cal Lutheran, 2006), Ph.D. (McGill, 1992)
Skin tissue engineering, bone tissue engineering, vascular tissue engineering, wound healing
10. Introduction to Bioengineering. (2)
Lecture, two hours; discussion, one hour; outside study, three hours. Preparation: high school biology, chemistry, mathematics, physics. Introduction to scientific and technological bases for established and emerging subfields of bioengineering, including biosensors, bioinstrumentation, and biosignal processing, biomechanics, biomaterials, tissue engineering, biotechnology, biological imaging, biomedical optics and lasers, neuroengineering, and biomolecular machines. Letter grading. Mr. Deming (F)
19. Fiat Lux Freshman Seminars. (1)
Seminar, one hour. Discussion of and critical thinking about topics of current intellectual importance, taught by faculty members in their areas of expertise and illuminating many paths of discovery at UCLA. P/NP grading.
99. Student Research Program. (1 to 2)
Tutorial (supervised research or other scholarly work), three hours per week per unit. Entry-level research for lower division students under guidance of faculty mentor. Students must be in good academic standing and enrolled in minimum of 12 units (excluding this course). Individual contract required; consult Undergraduate Research Center. May be repeated. P/NP grading.
100. Bioengineering Fundamentals. (4)
Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Mathematics 32A, Physics 1B. Fundamental basis for analysis and design of biological and biomedical devices and systems. Classical and statistical thermodynamic analysis of biological systems. Material, energy, charge, and force balances. Introduction to network analysis. Letter grading. Mr. Kamei (W)
M104. Physical Chemistry of Biomacromolecules. (4)
(Same as Biomedical Engineering CM104.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 30A, Life Sciences 2, 3. To understand biological materials and design synthetic replacements, it is imperative to understand their physical chemistry. Biomacromolecules such as protein or DNA can be analyzed and characterized by applying fundamentals of polymer physical chemistry. Investigation of polymer structure and conformation, bulk and solution thermodynamics and phase behavior, polymer networks, and viscoelasticity. Application of engineering principles to problems involving biomacromolecules such as protein conformation, solvation of charged species, and separation and characterization of biomacromolecules. Letter grading. Ms. Kasko (F)
M105. Biopolymer Chemistry and Bioconjugates. (4)
(Same as Biomedical Engineering CM105.) Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medial diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Letter grading. Mr. Deming (F)
M106. Topics in Biophysics, Channels, and Membranes. (4)
(Same as Biomedical Engineering CM106.) Lecture, three hours; discussion, one hour; outside study, eight hours. Enforced requisites: Chemistry 20B, Life Sciences 2, 3, 4, Mathematics 33B, Physics 1C, 4AL, 4BL. Coverage in depth of physical processes associated with biological membranes and channel proteins, with specific emphasis on electrophysiology. Basic physical principles governing electrostatics in dielectric media, building on complexity to ultimately address action potentials and signal propagation in nerves. Topics include Nernst/Planck and Poisson/Boltzmann equations, Nernst potential, Donnan equilibrium, GHK equations, energy barriers in ion channels, cable equation, action potentials, Hodgkin/Huxley equations, impulse propagation, axon geometry and conduction, dendritic integration. Letter grading. Mr. Schmidt (F)
M107. Polymer Chemistry for Bioengineers. (4)
(Same as Biomedical Engineering CM107.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisite: course M104 or M105. Fundamental concepts of polymer synthesis, including step-growth, chain growth (ionic, radical, metal catalyzed), and ring-opening, with focus on factors that can be used to control chain length, chain length distribution, and chain-end functionality, chain copolymerization, and stereochemistry in polymerizations. Presentation of applications of use of different polymerization techniques. Concepts of step-growth, chain-growth, ring-opening, and coordination polymerization, and effects of synthesis route on polymer properties. Lectures include both theory and practical issues demonstrated through examples. Letter grading. Mr. Deming (W)
110. Biotransport and Bioreaction Processes. (4)
Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: course 100, Mathematics 33B. Introduction to analysis of fluid flow, heat transfer, mass transfer, binding events, and biochemical reactions in systems of interest to bioengineers, including cells, tissues, organs, human body, extracorporeal devices, tissue engineering systems, and bioartificial organs. Introduction to pharmacokinetic analysis. Letter grading. Mr. Kamei (Sp)
120. Biomedical Transducers. (4)
Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 30A, Electrical Engineering 1 or Physics 1C, Electrical Engineering 100, Mathematics 32B. Principles of transduction, design characteristics for different measurements, reliability and performance characteristics, and data processing and recording. Emphasis on silicon-based microfabricated and nanofabricated sensors. Novel materials, biocompatibility, biostability. Safety of electronic interfaces. Actuator design and interfacing control. Letter grading. Mr. Grundfest, Mr. Schmidt (W)
(Same as Biomedical Engineering CM131.) Lecture, four hours; discussion, one hour; outside study, seven hours. Requisites: courses 100, 120, Life Sciences 2, 3, Physics 1A, 1B, 1C. Analysis of sensors based on measurements of fluctuating ionic conductance through artificial or protein nanopores. Physics of pore conductance. Applications to single molecule detection and DNA sequencing. Review of current literature and technological applications. History and instrumentation of resistive pulse sensing, theory and instrumentation of electrical measurements in electrolytes, nanopore fabrication, ionic conductance through pores and GHK equation, patch clamp and single channel measurements and instrumentation, noise issues, protein engineering, molecular sensing, DNA sequencing, membrane engineering, and future directions of field. Letter grading. Mr. Schmidt (Sp)
165EW. Bioengineering Ethics. (4)
(Formerly numbered 165.) Lecture, four hours; discussion, three hours; outside study, five hours. All professions have ethical rules that derive from moral theory. Bioethics is well-established discipline that addresses ethical problems about life, such as when do fertilized eggs become people? Should ending of life ever be assisted? At what cost should it be maintained? Unlike physicians, bioengineers do not make these decisions in practice. Engineering ethics addresses ethical problems about producing devices from molecules to bridges, such as when do concerns about risk outweigh concerns about cost? When are weapons too dangerous to design? At what point does benefit of committing to building devices outweigh need to wait for more scientific confirmation of their effectiveness? Bioengineers must be aware of consequences of applying such devices to all living systems. Emphasis on research and writing within engineering environments. Satisfies engineering writing requirement. Letter grading. Mr. Wu (W)
167L. Bioengineering Laboratory. (4)
(Formerly numbered 182A.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisite: Chemistry 20L. Laboratory experiments in fluorescence microscopy, bioconjugation, soft lithography, and cell culture culminate in design of engineered surface for cell growth. Introduction to techniques used in laboratories and their underlying physical or chemical properties. Case studies connect laboratory techniques to current biomedical engineering research and reinforce experimental design skills. Letter grading. Mr. Di Carlo, Mr. Wong (Sp)
M172. Design of Minimally Invasive Surgical Tools. (4)
(Same as Biomedical Engineering CM172.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 30B, Life Sciences 2, 3, Mathematics 32A. Introduction to design principles and engineering concepts used in design and manufacture of tools for minimally invasive surgery. Coverage of FDA regulatory policy and surgical procedures. Topics include optical devices, endoscopes and laparoscopes, biopsy devices, laparoscopic tools, cardiovascular and interventional radiology devices, orthopedic instrumentation, and integration of devices with therapy. Examination of complex process of tool design, fabrication, testing, and validation. Preparation of drawings and consideration of development of new and novel devices. Letter grading. Mr. Grundfest (Sp)
176. Principles of Biocompatibility. (4)
Lecture, four hours; discussion, two hours; outside study, six hours. Enforced requisites: course 100, Electrical Engineering 1 or Physics 1C, Mathematics 33B. Biocompatibility at systemic, tissue, cellular, and molecular levels. Biomechanical compatibility, stress/strain constitutive equations, cellular and molecular response to mechanical signals, biochemical and cellular compatibility, immune response. Letter grading. Mr. Wu (Sp)
177A. Bioengineering Capstone Design I. (4)
(Formerly numbered 182B.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisites: courses 167L, 176. Lectures, seminars, and discussions on aspects of biomedical device and therapeutic design, including topics such as need finding, intellectual property, entrepreneurship, regulation, and project management. Working in teams, students develop innovative solutions to address current problems in medicine and biology. Sourcing and ordering of materials and supplies relevant to student projects. Exploration of different experimental and computational methods. Scientific presentation of progress. Letter grading. Mr. Di Carlo, Mr. Wong (F)
177B. Bioengineering Capstone Design II. (4)
(Formerly numbered 182C.) Lecture, two hours; laboratory, six hours; outside study, four hours. Enforced requisite: course 177A. Lectures, seminars, and discussions on aspects of biomedical device and therapeutic design, including meetings with scientific/clinical advisers and guest lectures from scientists in industry. Working in teams, students develop innovative solutions to address current problems in medicine and biology. Students conduct directed experiments and computational modeling, give oral presentations, write reports, and participate in bioengineering design competition. Letter grading. Mr. Di Carlo, Mr. Wong (W)
180. System Integration in Biology, Engineering, and Medicine I. (4)
Lecture, three hours; discussion, two hours; outside study, seven hours. Enforced requisites: courses 100, 110, 120, Life Sciences 3, Physics 4BL. Corequisite: course 180L. Part I of two-part series. Molecular basis of normal physiology and pathophysiology, and engineering design principles of cardiovascular and pulmonary systems. Fundamental engineering principles of selected medical therapeutic devices. Letter grading. Mr. Dunn, Mr. Wu (W)
180L. System Integration in Biology, Engineering, and Medicine I Laboratory. (3)
Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 180. Hands-on experimentation and clinical applications of selected medical therapeutic devices associated with cardiovascular and pulmonary disorders. Letter grading. Mr. Dunn, Mr. Wu (Sp)
181. System Integration in Biology, Engineering, and Medicine II. (4)
Lecture, three hours; discussion, two hours; outside study, seven hours. Requisite: course 180L. Corequisite: course 181L. Part II of two-part series. Molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Fundamental engineering principles of selected medical therapeutic devices. Letter grading. Mr. Dunn, Mr. Wu (W)
181L. System Integration in Biology, Engineering, and Medicine II Laboratory. (3)
Lecture, one hour; laboratory, four hours; clinical visits, three hours; outside study, one hour. Corequisite: course 181. Hands-on experimentation and clinical applications of molecular basis of normal physiology and pathophysiology of selected organ systems; engineering design principles of digestive and urinary systems. Letter grading. Mr. Dunn, Mr. Wu (W)
M183. Targeted Drug Delivery and Controlled Drug Release. (4)
(Same as Biomedical Engineering CM183.) Lecture, three hours; discussion, two hours; outside study, seven hours. Requisites: Chemistry 20A, 20B, 20L. New therapeutics require comprehensive understanding of modern biology, physiology, biomaterials, and engineering. Targeted delivery of genes and drugs and their controlled release are important in treatment of challenging diseases and relevant to tissue engineering and regenerative medicine. Drug pharmacodynamics and clinical pharmacokinetics. Application of engineering principles (diffusion, transport, kinetics) to problems in drug formulation and delivery to establish rationale for design and development of novel drug delivery systems that can provide spatial and temporal control of drug release. Introduction to biomaterials with specialized structural and interfacial properties. Exploration of both chemistry of materials and physical presentation of devices and compounds used in delivery and release. Letter grading. Ms. Kasko (F)
188. Special Courses in Bioengineering. (4)
Lecture, four hours; discussion, one hour; outside study, seven hours. Special topics in bioengineering for undergraduate students taught on experimental or temporary basis, such as those taught by resident and visiting faculty members. May be repeated once for credit with topic or instructor change. Letter grading.
194. Research Group Seminars: Bioengineering. (4)
Seminar, three hours. Limited to bioengineering undergraduate students who are part of research group. Study and analysis of current topics in bioengineering. Discussion of current research literature in research specialty of faculty member teaching course. Student presentation of projects in research specialty. May be repeated for credit. Letter grading.
199. Directed Research in Bioengineering. (2 to 8)
Tutorial, to be arranged. Limited to juniors/seniors. Supervised individual research or investigation under guidance of faculty mentor. Culminating paper or project required. May be repeated for credit with school approval. Individual contract required; enrollment petitions available in Office of Academic and Student Affairs. Letter grading.